食管癌后程加速超分割放疗加甘氨双唑钠增敏的临床研究  

Clinical analysis for effect of late-course accelerated hyperfractionation and radiosensitizer(CMNa) for esophageal carcinoma

作　　者：高飞[1] 赵莺[1] 尹小祥[1] 叶宏勋[1] 周绍兵[1] 刘阳晨[1] 

机构地区：[1]泰兴市人民医院放疗科

出　　处：《临床肿瘤学杂志》2007年第7期514-516,共3页Chinese Clinical Oncology

摘　　要：目的:观察评价甘氨双唑钠(CMNa)配合放疗对食管癌的疗效和毒副反应。方法:96例食管癌患者随机分为两组:治疗组(放疗+CMNa)48例,前4周予常规分割照射DT40Gy/40f,后2周予超分割推量至DT60～66Gy/50～60f,5～6w,放疗同时使用CMNa每次800mg/m2,每周3次,从放疗开始连续使用至放疗结束;对照组30例只行放射治疗,剂量、分割方式同治疗组。治疗完成后评价疗效和不良反应。结果:治疗组总有效率(CR+PR)91.6%,完全缓解率(CR)52.1%;对照组总有效率75.0%,完全缓解率41.7%,两组间总有效率差异有统计学意义(χ2=4.75,P<0.05)。治疗组和对照组中位生存期分别为19个月和16个月,1、2年生存率治疗组分别为68.8%、50.0%,对照组分别为60.4%、39.6%,两组间差异无统计学意义(P>0.05)。治疗毒副反应主要是放射性肺炎、放射性食管炎和骨髓抑制,两组间差异无统计学意义。结论:CMNa合并放疗可明显提高食管癌的近期疗效,远期疗效略有提高,但差异无统计学意义,需要进一步研究。Objective：To observe the effects and toxic effects of radiosensilizer melronidazole am into acidum （CMNa） for esophageal cancer. Methods：Ninty-six patients were enrolled into two groups ： 48 cases in the treatment group who received radiosensitizer （CMNa 800mg/m^2 ,three times weekly） and radiotherapy, which the patients were first irradiated with CF DT40Gy/40f in 4 weeks ,then followed with LCAHF DT60-66 Gy/50-60f,5-6w in 2 weeks. Other 48 cases in the control group received radiotherapy alone. The method of radiotherapy in control group was as same as that in treatment group. Results：The overall responserate （CR ＋ PR） in the treatment group was 91.6% with a complete response rate（ CR）52. 1%. The overall response rate（ CR ＋ PR） in the control group was 25.0% with a complete response rate （CR）41.7%. The difference of overall response rate between two groups was statistically significant （P 〈 0.05）. The median survival time, 1 and 2-year survival rates were 19 months,68.8% and 50.0% for the treatment group, and 16 monthts,60. 4% and 39. 6% for the control group （P 〉 0. 05 ）respectively. The main toxic effect were radiation pneumonitis, radiation esophagitis and marrow suppression. There was no siginificant difference in toxity In the two groups（ P 〉 0. 05 ）. Conclusion：CMNa is radiosentizative to esophageal carcinoma. It could increase immediate response of esophageal carcinoma without severe toxicities.

关 键 词：食管癌 放射治疗 甘氨双唑钠 放疗增敏 后程超分割 

分 类 号：R735.1[医药卫生—肿瘤]