阿立哌唑与氯氮平对精神分裂症患者血糖代谢的影响  

A comparative study of blood-glucose metabolism between aripiprazole and clozapine in treatment of patients with schizophrenia

作　　者：易峰[1] 甄莉丽[1] 王进良[1] 许凌峰[1] 杨国平[1] 

机构地区：[1]江苏无锡市精神卫生中心,214151

出　　处：《临床精神医学杂志》2007年第4期253-253,共1页Journal of Clinical Psychiatry

摘　　要：目的:探讨阿立哌唑与氯氮平对精神分裂症患者血糖及血清C-肽水平的影响。方法:将60例精神分裂症患者随机分为两组,分别给予阿立哌唑与氯氮平治疗,于入院时及治疗3个月后分别检测空腹血糖浓度及血清C-肽水平。结果:在治疗3个月氯氮平组空腹血糖及C-肽显著升高,差异有显著性(P<0.01),阿立哌唑组治疗前后差异无显著性(P>0.05)。结论:氯氮平可显著升高血糖及血清C-肽水平,增加胰岛素分泌,而阿立哌唑对血糖、血清C-肽水平及胰岛素分泌无明显影响。Objective：To study the influence of aripiprazole and clozapine on blood-glucose and C-peptide in the treatment of schizophrenic patients. Method： Sixty schizophrenic inpatients were divided into aripiprazole group and clozapine group randomly, and then received treatment for 3 months. All the patients were tested fasting blood-glucose and C-peptide before and after treatments. Results：There were significant differences in the blood-glucose and C-pepltide before and after treatment in clozapine group （ P 〈 0.01 ）. No significant differences were found before and after treatment in aripiprazole group（ P 〉 0.05）. Conclusion：It is demonstrated that clozapine increase the fasting blood-glucose, C-peptide and the serum insulin, but aripiprazole has little influence on them.

关 键 词：阿立哌唑 氯氮平 血糖 C-肽 

分 类 号：R749.3[医药卫生—神经病学与精神病学]