西酞普兰与文拉法辛治疗老年抑郁症对照研究  

Comparative study of citalopram and venlafaxine in treatment of senile depression

作　　者：景艳玲[1] 王晓英[1] 王立钢[1] 孙艳[1] 孙平[1] 

机构地区：[1]山东青岛市精神卫生中心,266034

出　　处：《临床精神医学杂志》2007年第4期263-264,共2页Journal of Clinical Psychiatry

摘　　要：目的:比较西酞普兰和文拉法辛治疗老年抑郁症的疗效及安全性。方法:将52例老年抑郁症患者随机分为西酞普兰组和文拉法辛组。疗程6周。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)及治疗中出现的症状量表(TESS)评定疗效和不良反应。结果:两组总体疗效相仿,在治疗2周末时HAMD、HAMA评分有显著性差异,文拉法辛组减分率显著多于西酞普兰组。两组不良反应均较轻,安全性好。结论:西酞普兰是一种安全有效的抗抑郁药,可用于老年抑郁症患者。Objective：To compare the efficacy and safety of citalopram and venlafaxine in the treatment of senile depression. Method： Fifty-two patients with senile depression were randomly divided into citalopram group and venlafaxine group. The period of study was six weeks. The efficacy and side effects were evaluated by Hamilton depressive scale （HAMD）,Hamilton anxiety scale （HAMA） and treatment emergent symptom scale （TESS）. Rsults： Effects of two groups were similar. At the end of 2nd week, there were significant differences in the scores of HAMD and HAMA between two groups, and the reductive rates of them were significantly higher in veniafaxine group than in citalopram group. The side effects were less in both groups. Conelusion：Citalopram is an effective and safe antidepressant in the treatment of senile depression.

关 键 词：西酞普兰 文拉法辛 老年 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]