双酚A和四溴双酚A对大型溞和斑马鱼的毒性  

Toxicity of BPA and TBBPA to Daphnia magna and Zebrafish Brachydanio rerio

作　　者：刘红玲[1] 刘晓华[1] 王晓祎[1] 王晓蓉[1] 于红霞[1] 

机构地区：[1]南京大学环境学院污染控制与资源化研究国家重点实验室,南京210093

出　　处：《环境科学》2007年第8期1784-1787,共4页Environmental Science

基　　金：国家自然科学基金重点项目(20237010;20375015)

摘　　要：采用静态生物急性试验的方法,研究了双酚A和四溴双酚A对大型溞和斑马鱼的急性毒性和生命早期阶段的生长发育影响.结果表明,大型溞的幼溞接触不同浓度的双酚A和四溴双酚A,活动会受到抑制,甚至死亡,48 h的EC50分别为8.91和0.69 mg.L-1;对斑马鱼也有明显的毒性作用,其96 h的LC50分别为9.06和1.78 mg.L-1.根据化学物质对鱼类和溞类的毒性评价标准,这2个化合物都属于高毒物质.双酚A和四溴双酚A对斑马鱼生命早期阶段毒性影响的研究结果表明,对斑马鱼胚胎发育有明显抑制作用,可以造成胚胎发育畸形甚至死亡,斑马鱼胚胎72 h孵化畸形是双酚A的最敏感指标,EC50为2.90mg.L-1,72 h未孵化是四溴双酚A的最敏感指标,EC50为0.14 mg.L-1.双酚A和四溴双酚A对鱼卵发育有显著影响,双酚A对鱼卵有致畸作用,四溴双酚A抑制了鱼卵孵化.Acute toxicity of BPA and TBBPA to Daphnia magna, zebrafish （ Brachydanio rerio ） and development effects of zebrafish embryo were studied, and safety assessment was also made to Daphnia magna and zebrafish. The tested chemicals remarkably restrained the mobilization of Daphnia magna, which may cause them death. 48 h ECs0 values for D. magna were 8.91 and 0.69 mg·L^-1 respectively. In addition, the chemicals showed the toxicity effects on zebrafish, and 96 h LC50 values were 9.06 and 1.78 mg·L^-1 respectively. BPA and TBBPA remarkably retarded the development of zebrafish embryos, which may cause embryo abnormality and death. And the most sensitive toxicological endpoints to BPA and TBBPA were found, 72 h EC50 （ malformation and embryo do not hatch） values were 2.90 and 0.14 mg·L^-1 respectively. The results showed that zebrafish embryo should be the most sensitive to the tested chemicals. The results indicated that BPA and TBBPA were the pollutants with high toxicity, in which TBBPA had the higher toxicity. BPA is a potential teratogen to zebrafish embryos, while TBBPA restrains embryo from hatch.

关 键 词：双酚A 四溴双酚A 大型涵 斑马鱼 毒性 

分 类 号：X171.5[环境科学与工程—环境科学]