改进大鼠单侧脑梗塞模型的实验研究  

Study on Method for Eexperimental Cerebral Ischemia in Rat

作　　者：周锡英[1] 马宁[1] 张北奇[1] 张硕立[1] 于占久[1] 

机构地区：[1]河北省医学科学院病生理研究室,050021

出　　处：《河北医药》1997年第3期131-132,共2页Hebei Medical Journal

摘　　要：脑缺血损伤模型多采用全脑缺血或开颅结扎大脑中动脉等,两者或与临床患者发病过程相差甚远;或因手术创伤较大均未能广泛推广。我们改进了大鼠局灶性脑缺血模型,按Zea Longa的评分标准,全部为成功模型。模型组动物的脑梗塞体积、脑水肿、乳酸和SOD和MDA的变化,均与对照组有显著差异。模型有以下优点:解剖特点与人脑接近;手术创口小,定位准确,脑组织暴露外界时间短;梗塞部位与范围较恒定,重复性较好;术后病死率低,存活时间长。Under surgical microscope, the starting point of left middle cerebral artery (LMCA) was blocked with electronic solidify so that the blood flow in this areas will be stoped-a new method of the middle cerebral artery occlusion. About after 24 hours, these rats will have been measured include animal's behave and the content of water in brain, the mase of necrosis of cere-bral tissue, SOD level and MDA content. It suggested that the model have some advantages than the other model, which may accuratly location, and less damage, good repeative and so on.

关 键 词：脑缺血 动物模型 大鼠 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学] R－332[医药卫生—临床医学]