阿尔茨海默病相关因素1:1配对病例-对照研究  

A 1:1 Matched Case-control Study on Factors of Alzheimer’s Disease

作　　者：张玉凌[1] 黄河浪[2] 周义生[1] 

机构地区：[1]江西省南昌市疾病预防控制中心营养与慢性病防治所,江西南昌330006 [2]南昌大学公共卫生学院,江西南昌330006

出　　处：《中国慢性病预防与控制》2007年第4期328-330,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨阿尔茨海默病(alzheimer’sdisease,AD)可能的相关因素。方法采用1∶1配对病例-对照研究,在南昌及九江地区共选择经临床确诊的AD病人129例,以性别、年龄(±3岁)、文化程度作为配对条件,选择健康对照129例。收集相关的资料进行条件Logistic回归分析。结果多因素分析提示,性格孤僻、重大不良生活史和经常使用铝制炊具是AD的危险因素,OR值(95%CI)分别为2.486(1.075～6.638),4.125(1.706～12.249)和2.454(1.277～5.268);家庭经济状况良好和积极参加体育锻炼是AD的保护因素,OR值分别为0.324(0.106～0.828)和0.258(0.104～0.520)。结论AD与家庭经济状况、体育锻炼频率、性格、重大生活不良史和使用铝制炊具有关。Objective To investigate the factors of Alzheimer＇s Disease （AD）. Methods A 1：1 matched case-control study was conducted. The study included 129 patients of clinically diagnosed AD and 129 controls selected from Nanchang and Jiujiang areas. The data were analyzed by the conditional logistic regression. Results The results showed the unsociable personality （OR=2.486, 95%CI= 1.075- 6.638）, the history of great negative life events （OR =4.125, 95% CI= 1.706-12.249）, using cookers made of aluminum （OR =2.454, 95%CI=1.277-5.268） were identified as risk factors for AD. The good family income state （OR=0.324, 95%CI=0.106-0.828） and frequently physical exercises （OR=0.258, 95%CI=0.104-0.520） were protective factors for AD. Conclusion Alzheimer＇s Disease seems to be related to the income state, fl＇equency of physical exercises, personality, big negative life events, using cookers made of Aluminum.

关 键 词：阿尔茨海默病 病例对照研究 条件Logistic模型 

分 类 号：R749.16[医药卫生—神经病学与精神病学]