血管内皮生长因子D及其受体flt-4在肝癌中的表达及意义  

Expression of vascular endothelial growth factor D and its receptor flt-4 in hepatocellular carcinoma

作　　者：唐瑞峰[1] 张志明[1] 马景枝[2] 李智峰[1] 苑建磊[1] 齐帅[1] 田贵金[1] 孙朝[1] 

机构地区：[1]河北医科大学第四医院肝胆外科,河北石家庄050011 [2]河北医科大学第四医院检验科,河北石家庄050011

出　　处：《临床荟萃》2007年第18期1311-1314,F0003,共5页Clinical Focus

基　　金：河北省科学技术研究与发展计划项目(编号:062761317)

摘　　要：目的探讨肝细胞肝癌(HCC)中血管内皮生长因子D(VEGF-D)及其受体flt-4的表达以及与肝癌临床病理特征如淋巴结转移之间的关系。方法应用免疫组织化学染色法检测48例HCC、28例癌旁组织及12例正常肝组织中VEGF-D的表达及flt-4阳性淋巴管的计数,分析VEGF-D的表达与肝癌临床病理特征的关系。结果HCC中VEGF-D的表达显著高于癌旁和正常肝组织,分别为75.0%(36/48),50.0%(14/28)和41.7%(5/12)(P<0.01);VEGF-D的表达与肝癌淋巴结转移和临床分期呈正相关(P<0.05);VEGF-D及flt-4在有肝门淋巴结转移组中的表达明显高于无淋巴转移组(P<0.05);VEGF-D及其受体flt-4在肝癌组织中的表达具有明显的相关性(P<0.05)。结论VEGF-D及其受体flt-4在肝癌组织中呈高表达,并与肝癌的淋巴结转移密切相关。Objective To study the expression of vascular endothelial growth factor D（VEGF-D） and its receptor flt-4 in hepatocellular carcinoma（HCC） tissue and to determine whether the expressions of VEGF-D and flt-4 were associated with clinical pathologic characters. Methods The expressions of VEGF-D and flt-4 proteins were examined by immunohistochemistry in 48 HCC tissues and 28 adjancent tumor tissues and 12 normal tissues,and the correlation between VEGF-D expression and clinical pathologic character was analyzed. Results Imunohistochemical analysis revealed that expression of VEGF-D was higher in HCC tissue than that of adjancent tumor tissues and normal tissues, respectively 75.0 % （36/48）, 50.0 %（14/28） and 41.7 %（5/12）（ P 〈0.01）. The expression of VEGF-D was associated with lymph node metastasis and clinical stage （P 〈0.05）. The expressions of VEGF-D and flt-4 in lymphatic metastasis group were higher than those of no lymphatic metastasis group（ P 〈0.05） and there was a distinct relativity between the expression of VEGF-D and expression of flt-4 in HCC. Conclusion VEGF-D and fit-4 are commonly overexDressed in HCC and may contribute to lymph node metastasis.

关 键 词：肝肿瘤 内皮生长因子D 受体 细胞表面 淋巴转移 

分 类 号：R735.7[医药卫生—肿瘤]