胃癌患者血清和组织IL-1β水平变化及临床意义  

Relationship between gastric mucosa lnterleukin-1 beta expression and gastriccarcinogenesis

作　　者：李娜[1] 李长顺[1] 乔文[1] 薛挥[1] 吕颐菲[1] 

机构地区：[1]西安交通大学第一医院消化内科,陕西西安710061

出　　处：《胃肠病学和肝病学杂志》2007年第4期373-376,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的研究IL-1β与胃癌发生的相关性,探讨IL-1β在胃癌发生中的作用,为胃癌的防治提供新的思路。方法收集70例胃癌、45例癌旁和70例胃炎手术切除组织和胃镜下活检标本,采用免疫组化SABC法测定组织IL-1β蛋白表达水平;以双抗体夹心ELISA法测定胃癌、胃炎患者血清中IL-1β含量,并进行比较。结果胃癌患者血清IL-1β水平显著高于胃炎病人(P<0.05),且与临床分期有关,进展期胃癌高于早期胃癌(P<0.05)。IL-1β蛋白在胃癌、癌旁和胃炎中的表达率分别为65.95%、44.44%和22.50%;胃癌组IL-1β表达高于癌旁、胃炎组。低、未分化癌组织IL-1β的表达高于高、中分化癌组织(P<0.05);进展期胃癌高于早期胃癌(P<0.05)。结论胃癌患者血清、胃粘膜组织中IL-lβ表达高于胃炎组,提示胃粘膜IL-1β表达与胃癌的发生有一定的关系。Objectives To study the relationship between IL-1β expression and gastric cancer. Methods Gastric mucosa IL-1β was detected in 70 cancerous, 45 para-tumor and 70 gastritis patients with immunohistochemical staining. Serum IL-1β concentration in patients with gastric cancer and gastritis was determined using ELISA. Results Serum IL- -1β level in patients with gastric cancer was significantly higher than that in patients with gastritis （ P 〈 0.05 ）. IL-1β protein expression rate in gastric cancerous tissues （65. 95% ） was significantly higher than that in para-tumor （44.44%） and gastritis tissues （22.50%）, whereas significant difference existed between the latter two groups in IL- -1β expression rates. Conclusions This study suggests that elevated IL-1β expression might play some role in the onset and advancement of gastric cancer.

关 键 词：胃癌 IL-1Β 

分 类 号：R735.2[医药卫生—肿瘤]