青少年肌阵挛癫痫发作间期EEG-fMRI的研究  

Study on Interictal Epileptiform Discharges in Juvenile Myoclonic Epilepsy Patient with EEG-fMRI

作　　者：刘永宏[1] 杨旭红[1] 廖伟[2] 刘凌[1] 鄢波[1] 林旭[1] 席静[1] 徐鸿儒[1] 陈华富[2] 周东[1] 

机构地区：[1]四川大学华西医院神经内科,成都610041 [2]电子科技大学生命科学与技术学院,成都610054

出　　处：《生物医学工程学杂志》2007年第4期748-751,共4页Journal of Biomedical Engineering

基　　金：四川省卫生厅科研课题资助(060034)

摘　　要：采用同步脑电与功能磁共振(Simultaneous electroencephalography-correlated functional magnetic resonance imaging,EEG-fMRI)技术,研究青少年肌阵挛癫痫患者发作间期痫样放电时脑部血氧水平依赖(Blood oxygen level-dependent,BOLD)信号变化。结果发现:双侧大脑半球的激活及失活信号变化普遍对称且各自独立存在,信号由枕顶至额区逐渐减少。阳性激活区有:楔叶、岛叶、额中部内侧、小脑中线两侧及丘脑。阴性激活区有:双侧额前部、顶部及扣带后回。由此推断:以棘慢复合波为表现形式的同步的神经元活动可能反映了丘脑皮层BOLD信号的激活,而失活区域反映了异常放电时的脑功能的静息状态;这类激活在神经元的活动(EEG)与fMRI结果之间有很好的对应关系;EEG-fMRI是研究脑功能状态有效的方式。Using simultaneous EEG-correlated functional MRI （EEG-fMRI）, we studied the blood oxygenation level-dependent （BOLD） signals in a juvenile myoclonic epilepsy （JME） patient with interictal epileptiform discharges. Extensive and symmetric activation and deactivation areas were assessed in bilateral hemispheric regions respectively, and these signals decreased gradually from the parieto-occipital region to the frontal region. Activations were found in cuneus, insulae, mesial midfrontal region, midline and bilateral cerebellum and thalamus, while the deactivities were in the bilateral anterior frontal region and parietal region as well as the posterior cingulate gyri. These findings suggest that the synchronized neuronal activities represented by spike and wave complex in EEG be reflected in the activation of BLOD signals in thalamocortical regions. However, those regions of deactivation reflect the suspension of the default state of brain function resulting indirectly from this discharge. There is good correspondence between neuronal activity （EEG） and fMRI. The combination of EEG and fMRI is a powerful tool in studying brain function.

关 键 词：同步脑电与功能磁共振 发作间期癫痫样放电 血氧水平依赖 青少年肌阵挛性癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]