单涎酸神经节苷脂对Parkinson病大鼠纹状体内肾上腺髓质移植物的影响  

Effects of monosialoganglioside on adrenal medulla grafts in the rat model of Parkinson's disease

作　　者：秦毅[1] 速家震[1] 张国风[2] 

机构地区：[1]宁夏医学院人体解剖教研室,银川750004 [2]首都医学院神经科学研究所

出　　处：《中华器官移植杂志》1997年第1期28-30,共3页Chinese Journal of Organ Transplantation

基　　金：宁夏回族自治区卫生厅科研基金

摘　　要：用单延酸神经节苷脂（GM1）浸泡肾上腺髓质组织，将其移植到帕金森病大鼠纹状体内，观察GM1对移植物存活的影响。结果发现，应用GM1浸泡肾上腺髓质移植组大鼠的阿朴吗啡诱发旋转行为得到明显改善；脑组织切片可见在移植区内有许多存活的嗜铬细胞，部分细胞发出粗短的突起。本实验表明，GM1具有提高嗜铬细胞在受体脑内的存活率，并有诱导嗜铬细胞伸出突起的作用，从而促进了移植物功能的发挥。本实验还证实了浸泡给药方式的有效性，具有临床应用价值。Rat's adrenal medulla (AT group) or adrenal medulla soaked with monosialogan glioside (AGT group) were transplanted into the head of striatum of rat model of Parkinsonism.Apomorphine induced greater improvement in rotational behavior in AGT group than in AT group with significant difference. Immunocytochemical staining with Chromagranin A showed that a lot of positively stained cells were distributed in the graft area and some cells developed process in AGT group. Our results showed that the monosialoganglioside had effects of increasing the survival of chromaffin cells and inducing the cells to develop processes.

关 键 词：GM1 神经节苷脂 肾上腺髓质 纹状体 震颤性麻痹 

分 类 号：R742.505[医药卫生—神经病学与精神病学]