强心冲剂对心力衰竭家兔心脏质量指数及血浆血管紧张素Ⅱ的影响  

Effect of Qiangxin Powder on angiotensin Ⅱ in plasma of rabbit with cardia failure

作　　者：刘长玉[1] 张红霞[1] 

机构地区：[1]天津中医药大学第二附属医院心内科,天津300150

出　　处：《河北中医》2007年第5期461-462,共2页Hebei Journal of Traditional Chinese Medicine

基　　金：天津市卫生局资助课题(编号:990212)

摘　　要：目的观察强心冲剂对后负荷增加所致充血性心力衰竭家兔心脏质量指数及血浆血管紧张素Ⅱ(AngⅡ)水平的影响。方法采用实验性腹主动脉缩窄术建立家兔心力衰竭模型60只。假手术组:随机取家兔12只,分离腹主动脉而不结扎。术后3日开始用胃管灌服15mL蒸馏水,每日1次。模型组及给药组:造模手术3日后,剩余家兔随机分为4组,各12只。①模型组:每日灌胃15mL蒸馏水1次;②地高辛组:灌胃前2日,用15mL蒸馏水溶解0.05mg地高辛进行灌服,从第3日开始每只每日每次灌服0.025mg;③低剂量强心冲剂组:将3g强心冲剂粉末溶于15mL蒸馏水中灌服,每日1次;④高剂量强心冲剂组:将6g强心冲剂粉末溶于15mL蒸馏水中灌服。各组连续9日灌服。各组动物均普通饲料喂养,自由进水。观察心脏质量指数及血浆AngⅡ水平。结果模型组家兔心脏质量指数、AngⅡ水平明显高于假手术组(P<0.01);而强心冲剂组可明显降低其水平(P<0.01)。结论强心冲剂可能通过干预和调整心脏、神经-内分泌的激活而参与心力衰竭症状的改善。objective To observe the change of angiotensin Ⅱ in plasma of rabbit with cardia failure caused by aftercurrent load increase, and effect of Qiangxin Powder on angiotensin Ⅱ Methods 48 rabbit models with cardia failure were established by experimental aorta ventralis constriction. 12 rabbit in sham operation group were established by abruptio of aorta ventralis and no ligation. After three days of operation, 15 ml distilled water was carried on by drench, one time a day in sham operation group. 48 rabbit models with eardia failure were divided into 4 groups. Rabbit models in model group were lavaged by 15 ml distilled water, one time a day. Rabbit models in digoxin group were lavaged by 0.05 nag digoxin in 15 ml distilled water, one time a day. Rabbit models in low dosage of Qiangxin Powder group were lavaged by 3 g digoxin in 15 ml distilled water, one time a day. Rabbit models in high dosage of Qiangxin Powder group were lavaged by. 6 g digoxin in 15 ml distilled water, one time a day. Heart weight index and level of angiotensin Ⅱ in plasma were measured. Results Heart weight index and level of angiotensin Ⅱ in model group were higher than those in sham operation group （ P 〈 0.01 ） . Heart weight index and level of angiotensin Ⅱ in Qiangxin Powder group were lower than those in sham operation group （ P 〈 0.01 ）. Conclusion Qiangxin Powder can improve symptoms of cardia failure by intervention and reg- ulation of heart, nerve and endocrinic activation.

关 键 词：强心冲剂 心力衰竭 心脏质量指数 血管紧张素Ⅱ 

分 类 号：R-332[医药卫生] R322.11