吸烟对短暂性脑缺血发作患者血浆组织因子水平的影响  

Effect of cigarette smoking on the level of plasma tissue factor in transient ischemic attack patients

作　　者：拱忠影[1] 柳忠兰[2] 耿建红[2] 刘伟[3] 

机构地区：[1]天津市第一中心医院神经内科,天津300192 [2]中国医科大学附属第一医院神经内科 [3]天津医科大学总医院超声科

出　　处：《中华老年心脑血管病杂志》2007年第8期548-550,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的观察短暂性脑缺血发作(TIA)吸烟者血浆组织因子(TF)水平的变化及其临床意义。方法回顾分析29例TIA吸烟者(TIA吸烟组)和29例TIA不吸烟者(TIA不吸烟组)血浆TF水平变化,并选用24例健康吸烟者(健康吸烟组)和24例健康不吸烟者(健康不吸烟组)作为对照,同时从TIA吸烟者和健康吸烟者中选出12例戒烟者作为戒烟组。血浆TF水平检测采用双抗体夹心酶联免疫分析法。结果TIA吸烟组血浆TF水平明显高于TIA不吸烟组(P<0.05)和健康不吸烟组(P<0.01),健康吸烟组血浆TF水平明显高于健康不吸烟组(P<0.05);血浆TF水平随着吸烟程度的加重而增高,吸烟者血浆基础TF水平与吸烟指数呈正相关(r=0.450,P<0.001),吸烟2h后血浆基础TF水平明显升高,而戒烟2周后血浆基础TF水平恢复至近正常水平。结论长期吸烟致TIA患者血浆TF水平增高可能在脑血栓形成中发挥重要作用。Objective To explore the effect of cigarette smoking on the level of plasma tissue factor （TF） in patients with transient ischemic attack（TIA） and its clinical significance. Methods Twenty-nine smokers with TIA and 29 non-smokers with TIA were analyzed retrospectively. Twenty-four healthy smokers and 24 healthy non-smokers served as controls. Twelve ex-smokers served as ex-smoker group simultaneously. The level of TF was detected with two-layer antibody sandwich enzyme-linked immunosorbent assay （ELISA）. Results The level of plasma TF in smokers with TIA was higher than that in non-smokers with TIA（ P 〈0.05）and was much higher than that in healthy non-smokers（ P 〈0.01）. The level in healthy smokers was higher than that in healthy non-smokers（ P〈0.05）. It increased with smoking level and was positively correlated with smoking index （ r = 0. 450, P 〈0.05）. The basal level of TF increased 2 hours after smoking 1 cigarette and returned to normal level 2 weeks after ceasing smoking. Conclusion The level of plasma TF increased in smokers with TIA, and it may play an important role in cerebral thrombosis.

关 键 词：脑缺血发作 短暂性 吸烟 凝血致活酶 血栓形成 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]