抑癌基因PTEN在脉络膜黑色素瘤中的表达  

Tumor suppressor gene PTEN in choroidal melanoma

作　　者：钟文[1] 康凤英[2] 赵素贞[1] 田杰[1] 李国锋[1] 

机构地区：[1]山东省潍坊市人民医院眼科,261041 [2]潍坊医学院附属医院,山东省维坊市261041

出　　处：《眼科新进展》2007年第8期585-587,共3页Recent Advances in Ophthalmology

摘　　要：目的通过对脉络膜黑色素瘤(choroidal melanoma,CM)以及不同组织病理分类的CM中抑癌基因PTEN表达的观察,探讨CM中PTEN的表达与CM预后的关系。方法取已经病理学证实的54例CM患者石蜡包埋的组织进行切片。采用免疫组织化学法检测抑癌基因PTEN在CM和正常眼脉络膜组织中的表达,并且观察不同的组织病理分型、不同最大基底直径、不同年龄、不同位置的CM中抑癌基因PTEN的表达。结果CM和正常眼脉络膜组织中PTEN的表达率差异有显著性(P<0.01);不同的组织病理分型表达率差异有显著性(P<0.01);不同最大基底直径、不同年龄、不同位置的CM中抑癌基因PTEN的表达率差异无显著性(P>0.05)。结论CM可表达抑癌基因PTEN,表达的强弱与其病理分型有密切关系,但与患者的发病年龄、肿瘤的位置和肿瘤的最大基底直径无明显相关关系。Objective To investigate the expression of tumor suppressor gene PTEN in choroidal melanoma（CM） with varied histopathological typing, and to study the clinical significance of PTEN expression in choroidal melanoma. Methods A total of 54 cases of choroidal melanoma were emboded in paraffi liquid and sliced up. The expression of tumor suppressor gene PTEN were observed with immunohistochemical method in varied CM tissues Concerning differences with histopathological typing,largest tumor diametor, terms of age, and tumor location and also observed in normal eye choroidal tissues. Results The expression of tumor suppressor gene PTEN showed significant difference in normal eye tissues Compared with those in CM （ P 〈 0.01 ）, had statistical significance in CM with varied histopathological typing（P 〈0.01 ）. had no meaning in CM corceming difference in largest tumor diametor, terms of age and tumor location（P〉0.05）. Conclusion CM can hinder the expression of tumor suppressor gene FTEN, Which has closely relation with histopathological typing,but no relation with terms of age, tumor location and largest tumor diameter. PTEN may be a useful prognostic indicator for the treatment of CM.

关 键 词：脉络膜肿瘤 黑色素瘤 抑癌基因 PTEN 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]