Bcl-2、Bax在翼状胬肉中的表达及临床意义  

Expression of Bcl-2 and Bax in pterygium and its clinical significance

作　　者：颜美荣[1] 刘庚勋[2] 李正贤[1] 周一鸣[1] 彭昌福[1] 王芳[1] 

机构地区：[1]解放军第163医院眼科,湖南省长沙市410003 [2]解放军第163医院病理科,湖南省长沙市410003

出　　处：《眼科新进展》2007年第8期591-593,共3页Recent Advances in Ophthalmology

摘　　要：目的研究翼状胬肉中Bcl-2和Bax的表达及临床意义。方法采用免疫组织化学Elivision法检测20例翼状胬肉、10例正常结膜中Bcl-2和Bax的表达。结果20例翼状胬肉中Bcl-2阳性表达19例,Bax阳性表达16例;正常结膜中Bcl-2阳性表达2例,Bax阳性表达6例。经统计学处理,翼状胬肉和正常结膜2组间Bcl-2阳性表达差异有显著统计学意义(χ2=17.860,P<0.001),而Bax阳性表达2组间的差异无统计学意义(χ2=3.068,P>0.05)。结论翼状胬肉的发生发展与Bcl-2和Bax的表达失衡有关,可能是细胞异常增生和凋亡失衡的共同结果。Objective To study the expression of Bcl-2 and Bax in pterygium and its clinical significance. Methods The immunohistochemical Elivision method was used to examine the expression of Bcl-2 and Bax in pterygium（20 cases） and normal conjunctiva（ 10 cases）. Results The positive expression of Bcl-2 was 19 cases and 2 cases respectively in pterygium and normal conjunctiva. The positive expression of Bax was 16 cases and 6 cases respectively in pteryginm and normal conjunctiva. There was significant difference in expression of Bcl-2 between pterygium and normal conjunctiva （χ^2 = 17. 860,P 〈 0. 001 ）. There was no significant difference in expression of Bax between pterygium and normal conjunctiva0（χ^2 =3.068,P〉0.05）.Conclusion The disbalance of Bcl-2 and Bax may be a positive factor in the pathogenesis of pterygium,pterygium development may result from a co-operation of abnormal proliferation and disbalanced apoptosis.

关 键 词：BCL-2 BAX 翼状胬肉 凋亡 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]