乳腺浸润性导管癌癌周淋巴管密度及其临床意义  

Peritumor lymphatic microvessel density and its clinical significance in invasive ductual carcinoma of breast

作　　者：张杰[1] 牛娜[2] 李文通[2] 周风华[2] 郑洁[2] 张式暖[2] 

机构地区：[1]潍坊医学院解剖学教研室,山东潍坊261042 [2]潍坊医学院病理学教研室,山东潍坊261042

出　　处：《中华肿瘤防治杂志》2007年第17期1321-1323,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨乳腺浸润性导管癌(IDC)癌周淋巴管密度(LMVD)与其临床病理特征及预后的关系。方法:选取65例临床病理资料完整的乳腺IDC组织,用免疫组化二步法以单克隆抗体D2-40标记淋巴管内皮细胞,光镜下观察癌周LMVD。结果:乳腺IDCLM-VD为13.17±2.89,明显高于乳腺纤维腺瘤组织(4.21±2.76),两者差异有统计学意义,P=0.000。LMVD与年龄、组织学分级、绝经状态以及雌激素受体状况之间差异无统计学意义,P均>0.05;与肿瘤最大直径、腋窝淋巴结转移数目和pTNM分期之间差异有统计学意义,P均<0.05。高LM-VD组的5年DFS明显低于低LMVD组,乳腺癌LMVD与患者5年DFS呈负相关。结论:MVD在乳腺IDC的扩散转移中起重要作用,可作为选择乳腺IDC治疗方式及预测其淋巴结转移及预后的重要指标。OBJECTIVE： To investigate the relationship between peritumor lymphatic microvessel density（LMVD） and clinical pathologi-cal features and prognosis in patients with invasive duetual carcinoma of breast. METHODS： The data of 65 cases of invasive ductual carcinoma of breast were collected. Monoeolonal antibody D2-40 was used to mark endothelioeyte of lymphatic vessels by two-step immunohistoehemieal staining. Then lymphatic mierovessel density was observed under a mi-croscope. RESULTS： LMVD in invasive duetual carcinoma of breast was 13.17±2.89 which was significantly higher than that in fibroadenoma tissues of breast （4.21±2.76）, P=0.000. LMVD was closely related to the longest diameter of tumor, number of lymph node invaded, pT-NM stages（P〈0.05）, but not age, histological classification differenti-ation degree, climacteric status and ER status, P〉0. 05. The 5-year disease-free-survival （5y DFS） in patients with high LMVD was signifi-cantly lower than that in patients with low LMVD. The 5y DFS of pa-tients with invasive duetual carcinoma of breast was negatively related to LMVD. CONCLUSION： The increase of LMVD may play an important role in the development and metastasis of invasive duetual carcinoma of breast, and might be served as a tumour marker to adopt the therapy way and evaluate the prognosis of patients with invasive duetual carcino-ma of breast.

关 键 词：乳腺肿瘤 病理学 癌 导管 乳腺 淋巴管 病理学 淋巴转移 

分 类 号：R737.9[医药卫生—肿瘤]