奥沙利铂联合5-氟脲嘧啶持续静脉滴注48h及亚叶酸钙(双周疗法)治疗晚期大肠癌34例的临床观察  被引量:2

Clinical Study of 34 Cases on the Treatment of Advanced Colorectal Carcinoma with Oxaliplatin in Combination 5-Flouruorail Continuous Infusion(Biweek Schedule) and Leucovorin

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作  者:黎佳全[1] 曾嵘[1] 杨权烈[1] 

机构地区:[1]广东省梅州市人民医院,广东梅州514031

出  处:《河北医学》2007年第8期918-920,共3页Hebei Medicine

摘  要:目的:观察奥沙利铂联合5-氟脲嘧啶持续静脉滴注48h及亚叶酸钙(双周疗法)治疗晚期大肠癌的近期方疗效和不良反应.方法:全组病例采用静脉滴注奥沙利铂100mg/m^2、亚叶酸钙200mg/m^2,滴完亚叶酸钙之后5-FU500mg静脉注射,接着5-FU 3.0 g/m^2用输液泵持续静脉滴注 48h,每2周1次,2次为1周期.结果:全组CR 1例,PR15例,SD 9例,PD9例,总有效率(CR+PR)为47.06%(16/34),主要不良反应为恶心、呕吐、骨髓抑制、口腔粘膜炎、外周静脉炎,多数为Ⅰ~Ⅱ度以及轻度外周神经毒性.结论:奥沙利铂联合5-氟脲嘧啶持续静脉滴注48h及亚叶酸钙(双周疗法)治疗晚期大肠癌疗效较好,不良反应轻,患者耐受性良好,并且经济实用.: Objective: To evaluate the efficacy and toxicity of oxaliplatin in combination with 5 - Flouruorail continuous infusion 48 hours (biweek schedule} and leucovorin with advanced colorectal carcinoma. Method: All cases used Drip -injecting oxaliplatin 100mg/m^2. Leucovorin 200mg/m^2 and after dripping leucovorin ,5 - Fu 500mg into vein followed by dripping 5 - Fu 3, 0g/m^2 into vein lasting 48 hours were performed that were repeated per two weeds. Every four weeks was a cycle. Result: There were 1 CR, 15 PR, 9 SD and 9 PD in the group. The overall response rate was 47.06% ( 16/34). The major toxic reactions were nausea, vomiting, suppression of bone marrow, mucositis, peripheral phlebitis of grade I to H and peripheral neurotoxicity. Conclusion: Oxaliplatin in combination with 5 - Flouruorail continuous infusion 48 hours ( biweek schedule ) and leucovorin is a high response and cheap for advanced colorectal carcinoma with mild toxicity.

关 键 词:晚期大肠癌 化学疗法 奥沙利铂 5-氟尿嘧啶 亚叶酸钙 

分 类 号:R735.34[医药卫生—肿瘤]

 

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