Neurotrophin 3对本体感觉神经作用的研究进展  

The role for Neurotrophin 3 in proprioceptive sensory nerve

作　　者：王嵘[1] 邱勇[1] 

机构地区：[1]南京大学医学院附属南京鼓楼医院脊柱外科,江苏南京210008

出　　处：《医学研究生学报》2007年第7期774-775,779,共3页Journal of Medical Postgraduates

基　　金：南京市科技局人才培养基金资助项目(批准号:200306066)

摘　　要：Neurotrophin 3(NT-3)是本体感觉神经存活和发挥生理功能所必需的营养因子。在胚胎期缺失NT-3,可直接导致本体感觉神经元凋亡,进而导致本体感受器(肌梭)不能分化发育。同时,NT-3在本体感觉神经投射和形成突触联系中起关键的诱导作用。成年后缺失NT-3,也同样可导致本体感觉神经功能下降。在病理状态下NT-3可以保护本体感觉神经,并促进其恢复正常生理功能。Neurotrophin 3 （ NT-3 ） is required for proprioeeptive neuron survival and physiological function. During embryonic development, NT-3 deficient in developing muscle dues to loss of proprioeeptive neurons in dorsal root ganglia or their axons by apoptosis, and then to the absence of muscle spindles. The chemoattractant effect of NT-3 on dorsal root ganglion axons has been improved that NT-3 is a key requirement for the development of proprioeeptive projection to motor neurons. Depletion of NT-3 in the period of adult educes to the decline of the function of proprioeeption. NT-3 has extensive protective effect on proprioeeptive neuron and enhances them to restore the normal physiological function under the patho- logical state.

关 键 词：NEUROTROPHIN 3 本体感觉神经 背根神经节 肌梭 

分 类 号：R322.85[医药卫生—人体解剖和组织胚胎学]