NEUROTROPHIN

作品数：49被引量：151H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：郑世曦王嵘王劲松王松灵邱勇更多>>
相关机构：中国科学院首都医科大学南京大学医学院附属鼓楼医院河南大学更多>>
相关期刊：《Neural Regeneration Research》《Bulletin of the Chinese Academy of Sciences》《World Journal of Biological Chemistry》《Journal of Otology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划南京市科技局人才培养基金北京市自然科学基金更多>>
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Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway被引量：9
《Neural Regeneration Research》2023年第5期1067-1075,共9页Xin Sun Li-Yi Huang Hong-Xia Pan Li-Juan Li Lu Wang Gai-Qin Pei Yang Wang Qing Zhang Hong-Xin Cheng Cheng-Qi He Quan Wei 
supported by the National Key R&D Program of China,No.2020YFC2008502 (to QW);the National Natural Science Foundation of China,No. 82172534 (to QW)。
Although many therapeutic interventions have shown promise in treating spinal cord injury, focusing on a single aspect of repair cannot achieve successful and functional regeneration in patients following spinal cord ...
关键词：axon growth bone marrow mesenchymal stem cell exercise training mTOR neuroprotection NEUROTROPHIN REMYELINATION scar formation spinal cord injury synaptic plasticity 
Peptide WCPFSRSF ameliorates excitotoxicity and elevates synaptic plasticity in glutamate-damaged SH-SY5Y cells by modulating the PI3K/mTOR/EIF4E and BDNF/CREB/TrkB pathways被引量：1
《Food Bioscience》2022年第3期819-828,共10页Qi Zhang Lin Zheng Guowan Su Donghui Luo Mingtao Huang Yunzi Feng Mouming Zhao 
financially supported by the National Key R&D Program of China(2018YFD0901102);Guangdong Provincial Key R&D Program(2020B020226005);the Specific Fund Program for Basic and Applied Basic Research of Guangdong Province(2019A1515011952);Shandong Provincial Key R&D Program(LJNY202018).
The purpose of this study was to illustrate the beneficial effects and underlying mechanisms of peptide Trp-Cys-Pro-Phe-Ser-Arg-Ser-Phe (WCPFSRSF) against excitotoxicity by transcriptome analysis combined with western...
关键词：PEPTIDE EIF4E RNA-Sequencing analysis NEUROTROPHIN Synaptic plasticity 
Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression被引量：24
《Neural Regeneration Research》2021年第7期1344-1350,共7页Guang-Rui Chai Shu Liu Hong-Wei Yang Xiao-Long Chen 
sponsored by the National Natural Science Foundation of China, Nos.81200718(to HWY) and 81570866(to XLC)。
Quercetin is a widely-occurring flavonoid that protects against cancer, and improves memory and cardiovascular functions.However, whether quercetin exhibits therapeutic effects in diabetic retinopathy remains unclear....
关键词：ANGIOGENESIS diabetic retinopathy flavonoid heme oxygenase-1 INFLAMMATION NEUROTROPHIN QUERCETIN repair 
Small molecule activation of the neurotrophin hepatocyte growth factor to treat Alzheimer disease
《Neuroimmunology and Neuroinflammation》2021年第2期70-80,共11页John W.Wright Joseph W.Harding 
Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive neuron loses in memory-related brain structures.Five drugs have been approved by the FDA to treat Alzheimer's disease;however,these dr...
关键词：Alzheimer's disease brain-derived neurotrophic factor hepatocyte growth factor Trk receptor Met receptor angiotensin IV dihexa 
The crosstalk between Wnt and neurotrophin signaling pathways on neuronal differentiation of glial cells
《解剖学杂志》2021年第S01期91-91,共1页Ma Wei Yang Jinwei Li Chunyan Liu Jie Liu Wei Liang Yu Zang Chenghao Guo Jianhui Li Liyan 
Li Liyan(kmliyanl@163.com)。
Glial precursor cells are a group of glial cells surrounding the sensory neurons in dorsal root ganglia(DRG).In our previous study,we isolated and induced glial precursor cells derived from DRG to adopt a neuronal phe...
关键词：clarified PATHWAYS verified 
The role of the TrkB-T1 receptor in the neurotrophin-4/5 antagonism of brain-derived neurotrophic factor on corticostriatal synaptic transmission被引量：2
《Neural Regeneration Research》2020年第11期1973-1976,共4页Elizabeth Hernandez-Echeagaray 
supported by Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica Grants No.216515 and IN 211718。
This manuscript reviews the function and fundamental characteristics of the neurotrophins and their receptors to introduce the reader to the differential effects exhibited by the neurotrophins;brain-derived neurotroph...
关键词：BRAIN-DERIVED NEUROTROPHIC factor NEUROTROPHIN 4/5 occlusive striatum synergic TrkB-FL TrkB-T1 
Neurotrophin 3 hinders the growth and metastasis of hepatocellular carcinoma cells被引量：1
《Oncology and Translational Medicine》2020年第4期143-152,共10页Shengnan Zhao Aixia Chen Jingyu Cao Zusen Wang Weiyu Hu Fei Zhou Donghai Liang Hongsheng Yu 
Supported by grants from the National Natural Science Foundation of China(No.ZR2015HM025);Technology Development Program of Shandong Province,China(No.2011YD18003);CSCO-Hengrui Cancer Research Fund(No.Y-HR2018-293 and Y-HR2018-294).
Objective Neurotrophin 3(NTF3)is involved in numerous biological processes;however,its role in hepatocellular carcinoma(HCC)is not well studied.This study investigated NTF3 function in HCC progression and revealed its...
关键词：hepatocellular carcinoma tumor progression neurotrophin 3(NTF3) 
Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation被引量：3
《Neural Regeneration Research》2020年第6期1066-1070,共5页Xiang-Yang Zhang Feng Liu Yan Chen Wei-Chun Guo Zhao-Hui Zhang 
supported by the National Nature Science Foundation of China,No.81501053(to YC)
Brain-derived neurotrophic factor(BDNF)has robust effects on synaptogenesis,neuronal differentiation and synaptic transmission and plasticity.The maturation of BDNF is a complex process.Proprotein convertase 1/3(PC1/3...
关键词：cortical neuron ischemia NEUROTROPHIN oxygen-glucose deprivation precursor protein of BRAIN-DERIVED NEUROTROPHIC factor PROPROTEIN CONVERTASE PROPROTEIN CONVERTASE 1/3 
What is the role of Brain derived neurotrophic factor in Multiple Sclerosis neuroinflammation?
《Neuroimmunology and Neuroinflammation》2020年第3期291-299,共9页Viviana Nociti 
Multiple Sclerosis(MS)is a chronic,inflammatory and degenerative disease of the central nervous system(CNS)with an unknown etiology.The MS pathophysiology is due to altered bidirectional interactions between several i...
关键词：Multiple sclerosis NEUROINFLAMMATION brain derived neurotrophic factor NEUROPROTECTION NEUROTROPHIN therapeutic target 
Effect and mechanism of neurotrophin 3 on inhibiting dexamethasone-induced mouse MC3T3-E1 osteoblast apoptosis
《Journal of Hainan Medical University》2019年第22期17-21,共5页Ping Fan Xiu-Yuan Feng Nan Hu Dan Pu Xiao-Hong Lv Yin-Ing Sun Lan He 
National Natural Science Foundation of China(81900800);Natural Science Basic Research Plan in Shaanxi Province(2019JM-560).
Objective:To study the effect and mechanism of neurotrophin 3 (NT-3) on inhibiting dexamethasone (DEX)-induced mouse MC3T3-E1 osteoblast apoptosis.Methods:Mouse MC3T3-E1 osteoblasts were cultured and divided into grou...
关键词：NEUROTROPHIN 3 DEXAMETHASONE OSTEOBLAST APOPTOSIS PI3K/AKT/MTOR signaling pathway 
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