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BRAIN-DERIVED: 作品数：73被引量：370H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关期刊：《Chinese Journal of Traumatology》《Science China(Life Sciences)》《Science China Chemistry》《World Journal of Gastroenterology》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划湖北省自然科学基金国家教育部博士点基金更多>>

Trajectory of brain-derived amyloid beta in Alzheimer’s disease:where is it coming from and where is it going?: 《Translational Neurodegeneration》2024年第1期478-496,共19页Ni Liu Anaer Haziyihan Wei Zhao Yu Chen Hongbo Chao; supported by grants from the Startup Fund of Zhengzhou University(32213157);the Key Scientific Research Projects of Colleges and Universities in Henan Province(K20A180031);the Postdoctoral Startup Fund Zhengzhou University(997002);the National Natural Science Foundation of China(52208131).; Alzheimer’s disease(AD)is a progressive neurological disorder that primarily impacts cognitive function.Currently there are no disease-modifying treatments to stop or slow its progression.Recent studies have found th...; 关键词：Alzheimer’s disease Amyloid-β Periphery system Immune clearance

Central nervous system-derived extracellular vesicles:the next generation of neural circulating biomarkers?: 《Translational Neurodegeneration》2024年第1期674-691,共18页Rocío del Carmen Bravo-Miana Jone Karmele Arizaga-Echebarria David Otaegui; funded by the ISCⅢ(PI20/1253)and by the Basque Government through the ELKARTEK call(KK-2021/00009).; The central nervous system(CNS)is integrated by glial and neuronal cells,and both release extracellular vesicles(EVs)that participate in CNS homeostasis.EVs could be one of the best candidates to operate as nanosized ...; 关键词：Extracellular vesicles Circulating biomarkers Central nervous system-derived EVs Neural-derived EVs Brain-derived EVs Cerebrospinal fluid EVs Plasma EVs Neurodegenerative diseases

Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles被引量：1: 《Bone Research》2024年第1期137-152,共16页Weicheng Lu Jianfei Yan Chenyu Wang Wenpin Qin Xiaoxiao Han Zixuan Qin Yu Wei Haoqing Xu Jialu Gao Changhe Gao Tao Ye Franklin R.Tay Lina Niu Kai Jiao; This work was supported by the National Nature Science Foundation of China grant 82170978(to K.J.);the Distinguished Young Scientists Funds of Shannxi Province 2021JC-34(to K.J.).; Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary injury.Inflammasome-related proteins encapsulated in brain-deri...; 关键词：NEUROGENIC OSSIFICATION PATHOGENESIS

Culture and identification of neonatal rat brain-derived neural stem cells: 《World Journal of Stem Cells》2023年第6期607-615,共9页Qing-Zhong Zhou Xiao-Lan Feng Xu-Feng Jia Nurul Huda Binti Mohd Nor Mohd Hezery Bin Harun Da-Xiong Feng Wan Aliaa Wan Sulaiman; Project of Sichuan Department of Science and Technology,No.2016PJ552;the Project of Luzhou Department of Science and Technology,No.2016-R-70(18/24);the Project of Southwest Medical University of Science and Technology,No.15073 and 2015-YJ021;Orthopaedic diseases(Shang Antong)special research Project of Sichuan Medical Association,No.20220206070192.; BACKGROUND Timing of passaging,passage number,passaging approaches and methods for cell identification are critical factors influencing the quality of neural stem cells(NSCs)culture.How to effectively culture and iden...; 关键词：Neonatal rats Brain-derived neural stem cells CULTURE IDENTIFICATION

Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat被引量：1: 《Bioactive Materials》2023年第5期300-313,共14页Bai Xu Man Yin Yaming Yang Yunlong Zou Wenbin Liu Lianyong Qiao Jixiang Zhang Zhan Wang Yayu Wu He Shen Minghan Sun Weiyuan Liu Weiwei Xue Yongheng Fan Qi Zhang Bing Chen Xianming Wu Ya Shi Falong Lu Yannan Zhao Zhifeng Xiao Jianwu Dai; This work was supported by grants from the National Natural Science Foundation of China(No.81891002,No.32071338);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16040702,XDA16040704);National Key R&D Program of China(2017YFA0104701,2017YFA0104704);CAS Project for Young Scientists in Basic Research(YSRB073).; Neural stem progenitor cell(NSPC)transplantation has been regarded as a promising therapeutic method for spinal cord injury(SCI)repair.However,different NSPCs may have different therapeutic effects,and it is therefore...; 关键词：Spinal cord injury Brain-derived NSPCs Spinal cord-derived NSPCs H9 embryonic stem cell-derived NSPCs Collagen scaffolds

Simple Plasma Test Based on a MoSe_(2)SERS Platform for the Specific Diagnosis of Alzheimer’s Disease: 《Chemical & Biomedical Imaging》2023年第2期186-191,共6页Yan Zhou Jianyan Li Tingting Zheng Yang Tian; support from NSFC(21827814 for Y.Tian,21974049 for T.Zheng);funded by Shanghai Rising-star Program(20QA1403300);Innovation Program of Shanghai Municipal Education Commission(201701070005E00020).; As a significant Alzheimer’s disease(AD)-specific biomarker,the examination of brain-derived tau(BD-tau)is significant in terms of the diagnosis and differentiation of neurological disorders.In this research,sea urch...; 关键词：Surface enhanced Raman scattering SERS mapping MoSe_(2)microspheres charge transfer brain-derived tau

Brain-derived cell-free DNA被引量：1: 《Neural Regeneration Research》2022年第10期2213-2214,共2页Dean Southwood Sanyukta Singh Zac Chatterton; funded by The University of Sydney Postdoctoral Fellowship;funded by a National Health and Medical Research Council(NHMRC)-European Union Joint Program on Neurodegenerative Disease Research Grant(JPND2019-466-261&APP11912407).; Following cell death,DNA can be released into the blood plasma and other body fluids in the form of cell-free DNA(cfDNA).These DNA fragments are typically~167 bp in length,corresponding to the length of DNA wrapped ar...; 关键词：FETAL MOTHER ENDOGENOUS

Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules被引量：3: 《Translational Neurodegeneration》2022年第1期161-177,共17页Francesca Natale Salvatore Fusco Claudio Grassi; Ministero della Salute-Ricerca Corrente 2022 Fondazione Policlinico Universitario A.Gemelli IRCCS.; Neurodegenerative disorders are one of the most common causes of disability and represent 6.3%of the global burden of disease.Among them,Alzheimer’s,Parkinson’s,and Huntington’s diseases cause cognitive decline,rep...; 关键词：Extracellular vesicles Neurodegenerative diseases Stem cells Biomarkers Cognitive decline

Bioinformatics and system biology approach to identify influences of BDNF on depression model: 《中国药理学与毒理学杂志》2021年第9期695-696,共2页WEI Song-ren; OBJECTIVE The classic animal model of depression is CUMS,and one of the hypotheses is related to the decrease of brain-de⁃rived neurotrophic factor(BNDF)expression in the brain,and its corresponding animal model is BD...; 关键词：depression brain-derived neuro⁃trophic factors neurotransmitter hypothesis

Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Obsessive-Compulsive Disorder in a Japanese Population: 《Open Journal of Psychiatry》2021年第1期20-28,共9页Takeyuki Akimoto Chihiro Sutoh Masaru Kuno Daisuke Matsuzawa Tomihisa Niitsu Masaomi Iyo Eiji Shimizu; A role of lower brain-derived neurotrophic factor (BDNF) content in the pathogenesis of several mental illnesses has been suggested, especially in major depression. It is not known whether BDNF is involved in the path...; 关键词：Brain-Derived Neurotropic Factor (BDNF) Obsessive-Compulsive Disorder (OCD) ELISA DEPRESSION

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