Simple Plasma Test Based on a MoSe_(2)SERS Platform for the Specific Diagnosis of Alzheimer’s Disease  

作　　者：Yan Zhou Jianyan Li Tingting Zheng Yang Tian 

机构地区：[1]State Key Laboratory of Precision Spectroscopy,East China Normal University,Shanghai 200241,P.R.China [2]Shanghai Key Laboratory of Green Chemistry and Chemical Processes,Department of Chemistry,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200241,P.R.China

出　　处：《Chemical & Biomedical Imaging》2023年第2期186-191,共6页化学与生物医学影像（英文）

基　　金：support from NSFC(21827814 for Y.Tian,21974049 for T.Zheng);funded by Shanghai Rising-star Program(20QA1403300);Innovation Program of Shanghai Municipal Education Commission(201701070005E00020).

摘　　要：As a significant Alzheimer’s disease(AD)-specific biomarker,the examination of brain-derived tau(BD-tau)is significant in terms of the diagnosis and differentiation of neurological disorders.In this research,sea urchin-like MoSe_(2)microspheres were synthesized by hydrothermal synthesis,revealing significant SERS activity,and the enhancement factor(EF)reached 1.44×10^(7).The remarkable EF was mainly ascribed to the(i)charge transfer between MoSe_(2)and MB,(ii)MB molecule’s resonance effect,and(iii)molecular enrichment of porous structures.Through an aptamer-antibody sandwich method,we prepared a BD-tau SERS detection platform based on sea urchin-like MoSe_(2)microspheres.The liner range was 0.05−200.00 pM with a limit of detection(LOD)as low as 0.028 pM.Besides,the developed detection platform demonstrated excellent selectivity and enabled early diagnosis of AD patients.In general,the MoSe_(2)SERS detection platform can well detect the concentration of BD-tau in mouse plasma samples,showing great potential in specific recognition of AD among neurodegenerative diseases.

关 键 词：Surface enhanced Raman scattering SERS mapping MoSe_(2)microspheres charge transfer brain-derived tau 

分 类 号：R749.16[医药卫生—神经病学与精神病学]