Adult neurogenesis is a highly dynamic process that leads to the production of new neurons from a population of quiescent neural stem cells(NSCs).In response to specific endogenous and/or external stimuli,NSCs enter a...
supported by funding from FAPERGS under Grant No.1010267;FAPERGS/PPSUS;No.17/2551-0001;FAPERGS/PRONEX;No.16/2551-0000499-4;FAPERGS/CAPES under Grant No.19/25510000717-5;Conselho Nacional de Desenvolvimento Científico e Tecnologico under Grants Nos.4011645/2012-6 and#5465346/2014-6;Irish Research Council Government of Ireland Postdoctoral Fellowship;No.GOIPD/2022/792;Irish Research Council Enterprise Postdoctoral Fellowship;No.EPSPD/2022/112。
Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of research.This is reflected in a large d...
the National Key Research and Development Program of China(Grant No.2023YFC2412600);National Natural Science Foundation of China(Grant No.51971171).
Interactions between bone cells and neurocytes are crucial for endosseous nerve and ensuing bone regeneration.However,absence of neural stem cells in bone makes the innervation of implant osseointegration a major chal...
supported by NIH Grants R01NS092651 and R21NS111275-01;the Department of Veterans Affairs,BX001148 and BX005899(to PHK)。
Amyotrophic lateral sclerosis is a fatal multisystemic neurodegenerative disease with motor neurons being a primary target.Although progressive weakness is a hallmark feature of amyotrophic lateral sclerosis,there is ...
supported by the SIAT Innovation Program for Excellent Young Researchers,No.E1G0241001(to XZ)。
Brain injuries due to trauma or stroke are major causes of adult death and disability.Unfortunately,few interventions are effective for post-injury repair of brain tissue.After a long debate on whether endogenous neur...
Objective To observe the clinical efficacy of timing umbilical therapy for neurogenic bladder after spinal cord injury based on the midnight-noon and ebb-flow doctrine.Methods Sixty patients with neurogenic bladder af...
This work was supported by the National Nature Science Foundation of China grant 82170978(to K.J.);the Distinguished Young Scientists Funds of Shannxi Province 2021JC-34(to K.J.).
Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary injury.Inflammasome-related proteins encapsulated in brain-deri...
supported by grants from the Department of Science and Technology of Sichuan Province,Nos.2021ZYD0093(to LY),2022YFS0597(to LY),2021YJ0480(to YT),and 2022ZYD0076(to JY)。
Exosomes are cup-shaped extracellular vesicles with a lipid bilayer that is approximately 30 to 200 nm in thickness.Exosomes are widely distributed in a range of body fluids,including urine,blood,milk,and saliva.Exoso...
supported by the Ministry of Science and Technology of China (STI2030-2021ZD0202300);National Natural Science Foundation of China (NSFC 31820103006,32070971,32100768,32200776,and 32200792);Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01);ZJ Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology.
The seat of human intelligence is the human cerebral cortex,which is responsible for our exceptional cognitive abilities.Identifying principles that lead to the development of the large-sized human cerebral cortex wil...