Versatile strategies for adult neurogenesis:avenues to repair the injured brain  

作　　者：Junyi Zhao Siyu Liu Xianyuan Xiang Xinzhou Zhu 

机构地区：[1]The Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences [2]Faculty of Life and Health Sciences,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences [3]Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions

出　　处：《Neural Regeneration Research》2024年第4期774-780,共7页中国神经再生研究（英文版）

基　　金：supported by the SIAT Innovation Program for Excellent Young Researchers,No.E1G0241001(to XZ)。

摘　　要：Brain injuries due to trauma or stroke are major causes of adult death and disability.Unfortunately,few interventions are effective for post-injury repair of brain tissue.After a long debate on whether endogenous neurogenesis actually happens in the adult human brain,there is now substantial evidence to support its occurrence.Although neurogenesis is usually significantly stimulated by injury,the reparative potential of endogenous differentiation from neural stem/progenitor cells is usually insufficient.Alternatively,exogenous stem cell transplantation has shown promising results in animal models,but limitations such as poor long-term survival and inefficient neuronal differentiation make it still challenging for clinical use.Recently,a high focus was placed on glia-to-neuron conversion under single-factor regulation.Despite some inspiring results,the validity of this strategy is still controversial.In this review,we summarize historical findings and recent advances on neurogenesis strategies for neurorepair after brain injury.We also discuss their advantages and drawbacks,as to provide a comprehensive account of their potentials for further studies.

关 键 词：adult neurogenesis glia-to-neuron conversion ischemic stroke neurogenic niche NEUROINFLAMMATION stem cell transplantation traumatic brain injury 

分 类 号：R741[医药卫生—神经病学与精神病学]