Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression  

作　　者：Guang-Rui Chai Shu Liu Hong-Wei Yang Xiao-Long Chen 

机构地区：[1]Department of Ophthalmology,Shengjing Hospital of China Medical University,Shenyang,Liaoning Province,China [2]Department of Geratology,The First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China

出　　处：《Neural Regeneration Research》2021年第7期1344-1350,共7页中国神经再生研究（英文版）

基　　金：sponsored by the National Natural Science Foundation of China, Nos.81200718(to HWY) and 81570866(to XLC)。

摘　　要：Quercetin is a widely-occurring flavonoid that protects against cancer, and improves memory and cardiovascular functions.However, whether quercetin exhibits therapeutic effects in diabetic retinopathy remains unclear.In this study, we established a rat model of streptozocininduced diabetic retinopathy.Seventy-two hours later, the rats were intraperitoneally administered 150 mg/kg quercetin for 16 successive weeks.Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1β, interleukin-18, interleukin-6 and tumor necrosis factor-α in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome.Furthermore, quercetin inhibited the overexpression of TLR4 and NF-κBp65, reduced the expression of the pro-angiogenic vascular endothelial growth factor and soluble intercellular adhesion molecule-1, and upregulated the neurotrophins brain-derived neurotrophic factor and nerve growth factor.Intraperitoneal injection of the heme oxygenase-1 inhibitor zinc protoporphyrin blocked the protective effect of quercetin.These findings suggest that quercetin exerts therapeutic effects in diabetic retinopathy possibly by inducing heme oxygenase-1 expression.This study was approved by the Animal Ethics Committee of China Medical University, China(approval No.2016 PS229K) on April 8, 2016.

关 键 词：ANGIOGENESIS diabetic retinopathy flavonoid heme oxygenase-1 INFLAMMATION NEUROTROPHIN QUERCETIN repair 

分 类 号：R453.9[医药卫生—治疗学] R741[医药卫生—临床医学]