PROPROTEIN

作品数：8被引量：12H指数：2
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相关领域：医药卫生更多>>
相关作者：孙静许正宏更多>>
相关机构：中国医学科学院江南大学更多>>
相关期刊：《食品与发酵工业》《中国心血管病研究》《Journal of Cancer Therapy》《中国循环杂志》更多>>
相关基金：国家自然科学基金国家教育部博士点基金更多>>
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Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation被引量：3
《Neural Regeneration Research》2020年第6期1066-1070,共5页Xiang-Yang Zhang Feng Liu Yan Chen Wei-Chun Guo Zhao-Hui Zhang 
supported by the National Nature Science Foundation of China,No.81501053(to YC)
Brain-derived neurotrophic factor(BDNF)has robust effects on synaptogenesis,neuronal differentiation and synaptic transmission and plasticity.The maturation of BDNF is a complex process.Proprotein convertase 1/3(PC1/3...
关键词：cortical neuron ischemia NEUROTROPHIN oxygen-glucose deprivation precursor protein of BRAIN-DERIVED NEUROTROPHIC factor PROPROTEIN CONVERTASE PROPROTEIN CONVERTASE 1/3 
Efficacy of Shoushen granule on adenosine triphosphate binding cassette transporter A1, proprotein convertase subtilisin/kexin type 9 and toll-like receptor 4/nuclear factor kappa-B signaling pathway in ApoE-knockout mice被引量：5
《Journal of Traditional Chinese Medicine》2019年第4期524-534,共11页Li Shanshan Cao Hui Shen Dingzhu Chen Chuan Xing Sanli Dou Fangfang Jia Qingling 
Supported by the National Natural Science Foundation of China(The Role of TLR4/MyD88/NF-κB Signal Transduction Pathway and Expression of miRNA-146a in Atherosclerosis and the Intervention Mechanism of Shen Invigorating Compounds,No.81202731;Bushen Jiangzhi Recipe Protects Against Atherosclerosis via miR-27a-mediated PCSK9/ABCA1 Pathway,No.81873348);the Shanghai Natural Science Found(Inhibitory Mechanism of Chinese Herbal Compound,Shoushen Granule,for Invigorating Kidney in ApoE-/-Atherosclerosis Mouse Model by mir-19b Target Regulating ABCA1,No.16ZR1433900);the Shanghai Municipal Commission of Health and Family Planning Found(Effect of Kidney Invigoration and Lipid Intervention on the Atherosclerosis in ApoE-knockout Mice Based on mT OR signaling pathway of Autophagy System,No.201640217);Shanghai University of Traditional Chinese Medicine graduate"innovation ability training"special research projects(Mechanism of Bushen Jiangzhi Recipe Regulating TLR4/NF-κB Signaling Pathway Mediated by CD36 Through PCSK9 Targeted Regulation of apoE-/-mice Atherosclerosis,No.Y201858)
OBJECTIVE: To evaluate the efficacy of Shoushen granule, prepared with four Chinese medicinals, on the targeted regulation of adenosine triphosphate binding cassette transporter A1(ABCA1) through proprotein convertase...
关键词：Atherosclerosis ATP-BINDING cassette transporters PROPROTEIN convertases TOLL-LIKE receptor 4 NF-KAPPA B Shoushen GRANULE 
The different relations of PCSK9 and Lp(a) to the presence and severity of atherosclerotic lesions in patients with HeFH
《中国循环杂志》2018年第S01期141-142,共2页Yexuan Cao Huihui Liu Di Sun Jinglu Jin Ruixia Xu Yuanlin Guo Naqiong Wu Sha Li Yan Zhang Jing Sun Jianjun Li 
Background Relations of lipoprotein (a)(Lp[a]) and proprotein convertase substilisin/kexin type 9 (PCSK9) levels to coronary artery disease (CAD) have been well established in general population, while little is known...
关键词：lipoprotein(a) PROPROTEIN CONVERTASE substilisin/kexin type 9 CORONARY artery disease 
酶解褐藻寡糖的分离制备及其脂蛋白调节作用被引量：2
《食品与发酵工业》2018年第12期30-35,共6页陈岩君 窦文芳 李恒 史劲松 许正宏 
采用Isoptericola halotolerans CGMCC 5336褐藻胶裂解酶制备褐藻寡糖,通过液质联用技术(liquid chromatograph-mass spectrometer,LC-MS)对其组成进行初步分析,后经过凝胶色谱柱对其进行分离、纯化,得到4种组分,分别命名为Fr1、Fr2、Fr...
关键词：褐藻寡糖 凝胶分离 低密度脂蛋白受体(low-density-lipoprotein receptor LDLR) 前蛋白转化酶枯草溶菌素9(proprotein CONVERTASE subtilisin/kexin type 9 PCSK9) 
Value of serum PCSK9 for evaluating the severity in patients with type 2 diabetes mellitus and atherosclerosis
《Journal of Hainan Medical University》2017年第3期40-43,共4页Ji Ma Hong-Xia Shuai Juan Xiao 
National Natural Science Foundation of China(81601373).
Objective:To study the value of serum PCSK9 for evaluating the severity in patients with type 2 diabetes mellitus and atherosclerosis. Methods:Type 2 diabetic patients with carotid atherosclerosis who were treated in ...
关键词：Type 2 diabetes MELLITUS CAROTID ATHEROSCLEROSIS PROPROTEIN CONVERTASE SUBTILISIN kexin 9 Oxidative stress 
ABO血型与血脂和PCSK9相关性研究被引量：2
《中国心血管病研究》2016年第6期501-507,共7页高莹 李莎 徐瑞霞 郭远林 张彦 朱成刚 吴娜琼 孙静 李建军 
国家自然科学基金，首都临床特色应用研究基金，首都医学发展科研基金，北京自然科学基金，高等学校博士学科点专项科研基金
目的 探讨ABO血型和前蛋白转化酶枯草杆菌蛋白酶9（PCSK9）水平之间的联系.方法 人选507例行诊断性或治疗性冠状动脉造影检查的患者,收集基线数据并用ELISA法评价血浆PCSK9水平.结果 非O型受试者与O型受试者相比,总胆固醇（TC）[（5.07...
关键词：前蛋白转化酶枯草杆菌蛋白酶9 血脂 ABO血型 冠状动脉疾病 PROPROTEIN CONVERTASE subtilisin/kexin type 9 
Protein Folding Mediated by an Intramolecular Chaperone: Energy Landscape for Unimolecular Pro-Subtilisin E Maturation
《Advances in Bioscience and Biotechnology》2015年第2期73-88,共16页Ezhilkani Subbian Danielle M. Williamson Ujwal Shinde 
Efficient and precise assembly of polypeptides into native functional states is critical for normal cellular processes. Understanding how a specific structure is encoded in the polypeptide sequence and what drives the...
关键词：PROPEPTIDE Dependent Folding PROTEASE Activation Subtilases ENERGETICS PROPROTEIN Convertases 
Inhibition of EGFR Suppresses Ethyl Alcohol and Tobacco Cell Effects on Growth of Human Oral Keratinocytes and Human Papillomavirus 16 Entry as a Function of Furin
《Journal of Cancer Therapy》2015年第1期90-108,共19页Joel L. Schwartz Alexander Munaretto Sirlata Bagchi David Crowe Gonzalo Izaguirre 
Background: Reported are increased risks for malignant transformation in human oral keratinocytes (HOK) from ethyl alcohol (ETOH), tobacco products or human papilloma virus oncogenic subtype 16 (HPV 16) infections. We...
关键词：Ethyl Alcohol Tobacco Poly-Cyclic Aromatic Hydrocarbons Nitrosamines DNA Damage Tumor Suppressor Oncogene HPV 16 FURIN PROPROTEIN CONVERTASE EGFR INHIBITORS Phospho-L-Tyrosine INHIBITORS 
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