CD_(44s)和CD_(44v6)在大肠病变中表达及其预后的意义  

Clinical Significance and Expression of CD_(44s) and CD_(44v6) in Colorectal Lesion

作　　者：许东哲[1] 金哲洙[1] 李瑞永[1] 

机构地区：[1]延边大学附属医院普通三外科,吉林延吉133000

出　　处：《中国误诊学杂志》2007年第19期4448-4449,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:明确CD44s和CD44v6在大肠病变中表达的临床意义。方法:应用免疫组织化学SP法检测85例大肠癌和28例大肠腺瘤及36例癌旁正常肠黏膜中CD44s和CD44v6蛋白表达与分布和临床意义。结果:CD44s和CD44v6在大肠腺癌中表达率分别为67.1%和92.9%,在伴有不典型增生的大肠腺瘤组织中分别为66.7%和88.9%,两者与癌旁正常肠黏膜组织相比,有显著差异(P<0.01)。CD44s和CD44v6蛋白阳性过度表达与大肠癌的临床Duke′s分期密切相关(P<0.01),5 a生存期不足5 a组CD44v6阳性率明显增高(P<0.05)但CD44s和CD44v6蛋白阳性表达均与大肠腺癌分化程度、有无淋巴转移及远处转移不相关(P<0.01)。结论:CD44s和CD44v6蛋白阳性表达对大肠癌早期诊断有一定意义,尤以CD44v6意义更大。而且,CD44v6对大肠癌癌患者估计预后有一定意义。Objective：To invesgatethe the significance of the expression of CD44s and CD44.6 in colorectal adenocarcinomas. Methods ：To detect the CD44s and CD44.6 proteins in 85 cases of colorectal adenocarcinomas, 28 cases of colorectal adenonoma with dysplasia, and 36 cases peripheral normal mucosa of cancer by SP （streptavidinHRP） immunohistochemical method. Result：The postive expression rate of CD44s and CD44v6 was 67. 10% and 92.90% in cancer foci,respectlvely,and 66.70% and 88. 90% in adenoma withdysplasia, respectively. It was significant comparing with the postive rate of the normol mucosa（P〈0. 01） . As well as,the over-expression of CD44v6 was related with Duke＇s stage of colorectal adenocarcinoma （P〈0. 01）. Furthermore, the expression of CD44.6 was higher in those patients with less 5 years survival （P〈0.05） But both the CD441 and CD44.6 were not related with the differentiation,lymph node and distand metastasis of colorectal adenocarcinoma. Conclusion：The expression of CD44s and CD44v6 proteins has a significance in early diagnosis of coloreetal adenocarcinoma, especially CD44v6 and the detecting of CD44v6 protein is a possibal prognostic factor of colorectal adenocarcinoma.

关 键 词：结直肠肿瘤/病理学 腺瘤/病理学 抗原 CD44/分析 免疫组织化学 

分 类 号：R735.340.21[医药卫生—肿瘤]