复胃冲剂治疗大鼠胃癌癌前病变的疗效与抗氧化水平观察  

Effect of Fuwei Chongji on Chemoprevention and Anti-Oxidative Activities of the Precancerous Lesion in Rat Glandular Stomach

作　　者：潘碧霞[1] 史奎雄[1] 伍凤娟 宋建明 尹浩然[2] 朱正刚[2] 

机构地区：[1]上海第二医科大学医学营养教研室,200025 [2]上海第二医科大学附属瑞金医院外科,200025

出　　处：《上海第二医科大学学报》1997年第3期164-166,共3页Acta Universitatis Medicinalis Secondae Shanghai

基　　金："八五"国家中医药管理局攻关项目!85-919-01-01

摘　　要：饮用MNNG水造成大鼠胃腺癌前病变异型增生模型。分组饮用中药复胃冲剂、维酶素、含硒酵母、普通酵母、复胃冲剂＋含硒酵母、复胃冲剂＋MNNG、自来水（对照）等水溶液6周。结果发现，复胃冲剂每天10g／kg组、含硒酵母组、复胃冲剂5g／kg＋含硒酵母组的胃癌发生率显著低于对照组（P＜0．001），复胃冲剂组血清蛋白含量显著高于其它组（P＜0．05）。对照组的胃组织LPO与SOD显著高于其它组（P＜0．05）。N - methyl- N' - nitrosoguanidine (MNNG)was administered in drinking water to Wistar rats to induce the model of precancerous lesion in glandular stomach. Then, the surviving rats with precancerous lesion were divided into groups. Fuwei chongji (FW), Weimeisu, Yeastselenium(-Yse), Yeast(Y), FW combined Yse, FW combined MNNG and water (control group) were administered for 6 weeks. Finally, the stomach of every rat was examined grossly and microscopically and the anti -oxidative activity was tested. The incidence of glandular stomach cancer in all of the groups FW2(10g· kg-1· d-1), FW1(5g· kg -1·d-1)+YSe(560μg· kg-1·d-1)+)and Yse(2g· kg-1·d-1)+)was found to be lower than that in control group (P<0.001), the content of serum protein in both FW1 and FW2 groups was higher than other groups (P<0.05), the gastric content of lipid peroxide (LPO) and the activity of superoxide dismutase (SOD) in control group is higher than other groups (P<0.05).

关 键 词：复胃冲剂 癌前病变 胃肿瘤 抗氧化 

分 类 号：R273.52[医药卫生—中西医结合]