N-乙酰化转移酶基因多态性与肺癌易感性关系的研究进展  

Advance of researches on relationship between N-acetyltransferase genetic polymorphisms and susceptibility to lung cancer

作　　者：郭占林[1] 高旭东[1] 

机构地区：[1]内蒙古医学院第一附属医院胸心外科,呼和浩特010059

出　　处：《国际呼吸杂志》2007年第16期1224-1226,共3页International Journal of Respiration

基　　金：内蒙古自然科学基金资助项目（编号：200607010929）;内蒙古医学院附属医院重大科研资助项目

摘　　要：代谢酶在外源性致癌物的体内代谢中起重要的激活与灭活作用。N-乙酰化转移酶（arylamine N-acetyltransferases,NAT）是人体内重要的致癌物灭活酶。编码代谢酶的基因存在着多态性现象,可导致代谢酶活性不同,使外源性致癌物在体内代谢存在个体间差异。个体对肺癌的易感性不仅与致癌物的暴露有关,还与代谢酶基因多态性相关。本文就NAT及其与肺癌易感性关系进行综述。Most carcinogens are metabolized in the organism via complex enzymatic mechanisms involving both activation and detoxification reactions. Detoxifiction is mainly performed by the N- acetyltransferases （NAT）. However, several genes coding for enzymes involved in the carcinogens＇ metabolism are polymorphic, resulting in wide interindividual variability in enzymatic activities. Individual susceptibility to develop lung cancer could therefore depend not only on exposure to carcinogens, but also on genetic capacity to activate or inactivate carcinogens. This article summarizes the state of knowledge on NAT polymorphisms and lung cancer susceptibility.

关 键 词：肺肿瘤 易感性 N-乙酰化转移酶 基因多态性 

分 类 号：R734[医药卫生—肿瘤]