低氧诱导因子-1与脑梗死  

Hypoxia Inducible Factor-1 and Cerebral Infarction

作　　者：徐仁佃[1] 陶玉慧[1] 易娟[1] 杨云珠[1] 吴成斯[1] 吴裕臣[1] 

机构地区：[1]南昌大学第一附属医院神经科,330006

出　　处：《国际脑血管病杂志》2007年第7期541-544,共4页International Journal of Cerebrovascular Diseases

基　　金：江西省卫生厅科技基金资助项目（编号1056067）

摘　　要：低氧诱导因子-1（HIF-1）是低氧诱导因子家族中最先发现的蛋白因子，组织低氧时，HIF-1表达显著增加。HIF-1是缺氧环境的重要调节因子，对低氧反应性基因的转录有调控作用，并参与低氧反应的信号转导过程。轻度缺氧时，HIF-1产生缺氧耐受性，发挥神经保护作用，长期重度缺氧时，诱导神经细胞凋亡，具有神经毒性作用。最近的研究表明，HIF-1可能与脑梗死有关。文章就HIF-1概况、低氧活性调节以及与脑梗死的可能关系进行了综述。Hypoxia inducible factor-1 （HIF-1） is a protein factor first found in the family of hypoxia inducible factors. The expression of HIF-1 significantly increases during tissue hypoxia. HIF-1 is an important regulatory factor in a hypoxic environment, and it has regulatory effect on transcription of hypoxia responsive gene, and participates in signal transduction processes of hypoxia response. HIF-1 induces hypoxia tolerance and exerts neuroprotective effect during mild hypoxia. It induces neuronal apoptosis and has a neurotoxic effect during prolonged severe hypoxia. Recent studies have suggested that HIF-1 may be associated with cerebral infarction. This paper reviews the general situation of HIF-1, the regulation of HIF-1 activity and their possible relations with cerebral infarction.

关 键 词：低氧诱导因子-1 脑梗死 发病机制 缺氧 

分 类 号：R743.31[医药卫生—神经病学与精神病学]