1.23%氟化泡沫预防儿童乳牙龋的两年临床观察  

A two-year randomized clinical trial of 1.23 % fluoride foam on dental caries increment in primary teeth

作　　者：江汉[1] 台保军[2] 杜民权[1] 黄薇[1] 郭颖[1] 

机构地区：[1]武汉大学口腔医学院预防科,430079 [2]口腔生物医学工程教育部重点实验室

出　　处：《中华口腔医学杂志》2007年第8期456-459,共4页Chinese Journal of Stomatology

基　　金："十五"国家科技攻关计划(2004BA720A24)

摘　　要：目的评价专业应用氟化泡沫预防儿童乳牙龋的作用。方法应用双盲、群组随机、安慰剂对照的临床试验方法,对来自15个班的392名3～4岁儿童以班为单位按随机数字表法分为两组,试验组(8个班)的学生每半年应用1次氟化泡沫,对照组(7个班)应用安慰剂,观察2年。使用聚类统计分析模式评价研究的主要结果,采用独立样本的 t 检验比较两组间基线和2年后新龋增加量的差异。结果 2年后试验组所有牙面新生龋面均是3.8,对照组是5.0,龋齿降低率为24.2%,两组相比差异有统计学意义(P<0.05);与对照组相比,试验组邻面龋齿降低率为37.6%(P<0.01)。虽然试验组在颊舌面新生龋面均低于对照组,但是两组相比差异无统计学意义(P>0.05)。在(牙合)面,两组新生龋面均差异无统计学意义(P>0.05)。结论每半年专业应用1次1.23%氟化泡沫可有效顶防儿童乳牙龋的发生。Objective To evaluate the effect of bi-annual professional application of 1.23% fluoride foam on caries reduction in the primary dentition over a two-year period. Methods In a double- blind, cluster-randomised, placebo-controlled trial, 392 children aged 3-4 years from 15 classes were randomly assigned to two groups on a school class basis. The experimental group （8 classes） received a biannual fluoride foam application, and the placebo control group （7 classes） received the placebo. The analysis of caries increment was based on the class as the unit of analysis. The independent-samples t tests were performed to compare the differences in caries indices at baseline and caries increments between the two groups. Results The mean caries increment in foam group was 3.8 dmfs while it was 5.0 dmfs in the placebo control group, resulting in 24.2% caries reduction （P 〈 0. 05 ）. The experimental group had a 37.6% caries reduction on approximal surfaces compared with the placebo control group （P 〈 0. 01 ）. Although the mean dmfs increment of bucco-lingual surfaces was lower in the experimental group than that in the control group, it was not statistically significant （ P 〉 0. 05 ）. No significant difference in the mean caries increment was observed on occlusal surfaces between the two groups （ P 〉 O. 05 ）. Conclusions Bi-annual professional application of fluoride foam was effective in reducing the increment of dental caries in the primary teeth.

关 键 词：龋齿 氟化物 牙疾病预防 

分 类 号：R788.1[医药卫生—口腔医学]