介孔分子筛孔道结构对药物巯甲丙脯酸释放性能的影响  

Effect of Mesoporous Silica Pore Structure on the Release Profiles of Captopril Drug

作　　者：曲凤玉[1] 崔凌飞[1] 黄世英[2] 朱广山[2] 

机构地区：[1]哈尔滨师范大学化学系,哈尔滨150080 [2]吉林大学无机合成与制备化学国家重点实验室,长春130023

出　　处：《高等学校化学学报》2007年第8期1440-1442,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:29873017;20101004)资助

摘　　要：A series of mesoporous silica with variable pore structures were prepared.The influence of mesoporous structure on drug release profiles was studied.It is found that mesoporous pore structure has a great effect on the drug release rate.The cubic pore structure MCM-48 has a faster drug release rate than that of MCM-41 system;while SBA-16 with 'cage-like' pore structure system has the lowest drug release rate.A series of mesoporous silica with variable pore structures were prepared. The influence of mesoporous structure on drug release profiles was studied. It is found that mesoporous pore structure has a great effect on the drug release rate. The cubic pore structure MCM-48 has a faster drug release rate than that of MCM-41 system; while SBA-16 with ＂cage-like＂ pore structure system has the lowest drug release rate.

关 键 词：介孔分子筛 孔道结构 巯甲丙脯酸 释放性能 

分 类 号：O614[理学—无机化学]