去甲氨噻肟酸乙酯的合成研究  

Synthesis of Ethyl-demethylaminothiazolyloximate

作　　者：程清蓉[1] 刘志雄[2] 李翔[2] 喻宗沅[2] 

机构地区：[1]武汉工程大学化工与制药学院湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430074 [2]湖北省化学研究院,湖北武汉430073

出　　处：《化学世界》2007年第8期480-482,463,共4页Chemical World

摘　　要：去甲氨噻肟酸乙酯是合成头孢菌素类抗生素的重要中间体之一。以4-氯乙酰乙酸乙酯为起始原料,采用一锅法,一个单元操作完成肟化、环合制备去甲氨噻肟酸乙酯,总收率达91%。本工艺削减了大量有机溶剂的使用,简化了反应操作,缩短了反应周期。Ethyl demethylaminothiazolyloximate is one of the important medical intermediates, which forms side semisynthetic cephalosporins. It was synthesized with ethyl 4-chloroacetate as raw material, and a sequential process of continuous adding reactants to carry out oximation and cyclocondensation in one reactor was used. yield was 91%. The technology not only eliminates the use of large quantity of organic solvents but also operation and shortens total reaction time. chains of combined The total simplifies

关 键 词：去甲氨噻肟酸乙酯 肟化 环合 氨噻肟酸 头孢菌素类抗生素 一锅法 

分 类 号：TQ252.5[化学工程—有机化工]