T淋巴细胞亚群与斑秃发病关系的研究  

Studies on the relationship between T lymphocyte subtypes and alopecia areata

作　　者：黄卫宁[1] 侯显曾[1] 卢浩锵[1] 卢慧敏[2] 徐霞[3] 

机构地区：[1]广州医学院第一附属医院皮肤科,广东广州510120 [2]广州医学院第一附属医院儿科,广东广州510120 [3]广州医学院第一附属医院检验系,广东广州510120

出　　处：《岭南皮肤性病科杂志》2007年第4期208-210,共3页Southern China Journal of Dermato-Venereology

基　　金：广东省卫生厅资助项目(项目编号:A2005273)

摘　　要：目的:探讨T细胞亚群(CD3+、CD4+、CD8+T)在斑秃发病中所起的作用。方法:用流式细胞仪分别检测斑秃患者PBMC中CD3+、CD4+、CD8+T淋巴细胞的表达水平。结果:重型斑秃、轻型斑秃的CD4+T淋巴细胞表达高于正常对照组,且差异有统计学意义;重型斑秃、轻型斑秃的CD8+T淋巴细胞表达亦高于正常对照组,且差异有统计学意义;CD3+T淋巴细胞表达、CD4+/CD8+比值较正常对照升高,差异无统计学意义。结论:提示了由T淋巴细胞介导的斑秃的发病机理,CD8+和CD4+T淋巴细胞在其发病过程中起到重要作用,两者协同作用导致毛囊受损。Objective ：To study the relationship between the expression of T lymphocyte subtypes and alopecia areata （AA）. Methods：CD4^＋ ,CD8^＋ CD3^＋ T lymphocytes were sorted out by flow cytometry. Results：The expression of CD4^＋ and CI）8^＋ lymphocytes in patients with AA was Significandy increased than that in controls. The expression of CD3 lymphocytes and the ratio of CD4^＋/ CD8^＋ in AA were slightly increased compared with controls, but the difference was not significant. Conclusion：The study indicates that AA is a T lymphocyte mediated tissue -restricted autoimmune disease. CD4^＋ and CD8^＋ T lymphocytes play an important role in the pathogenesis of AA.

关 键 词：斑秃 T淋巴细胞 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]