乙丙昔罗中杂质限量检查方法的研究  

Studies on the Determination of Impurities in Efaproxiral

作　　者：杨辉[1] 张桂明 李秀荣[3] 郑立卿[1] 张嫡群[4] 

机构地区：[1]河北北方学院药理教研室,河北张家口075000 [2]河北省赤城县公安局,河北赤城075500 [3]北京市石景山医院药材科,北京石景山100043 [4]河北医科大学新药研发中心,河北石家庄050017

出　　处：《河北北方学院学报（医学版）》2007年第5期6-8,共3页Journal of Hebei North University:Medical Edition

摘　　要：目的:探讨薄层层析法(TLC)用于乙丙昔罗中杂质限量检查的效果。方法:以硅胶GF254薄层板为吸附剂,石油醚:乙酸乙酯:冰醋酸(1.0∶0.5∶0.04,v/v)为展开剂,检测波长254nm,比较供试品与杂质斑点的大小和颜色。结果:产品所含杂质量小于1%。结论:该方法可用于乙丙昔罗的杂质限量检查,效果良好。Objective： To set up a TLC method for the determination of the impurities in efaproxiral.Methods： SG GF254 for thin-layer chromatography was used as the stationary phase;Petroleum ether： acetic ether： glacial acetic acid（1.0 ： 0. 5 ： 0. 04,v/v）were used as the mobile phase;The UV detection wave was set at UVL 254nm. The size and color of the spot of the production and the impurity on the TLC were Compared. Results： The impurity quantity contained in the product is less than 1%. Conclusion： The method can be ap- plied to the determination of the impurities in efaproxiral.

关 键 词：乙丙昔罗 杂质限量 薄层层析法 

分 类 号：R914[医药卫生—药物化学]