表皮生长因子受体、血管内皮生长因子和Ki-67在老年非小细胞肺癌患者中的表达及意义  

Expression of epidermal growth factor receptor,vascular endothelial growth factor and Ki-67 in aged people with non-small cell lung cancer

作　　者：黄方[1] 吴波[2] 钱小明[1] 宋勇[3] 

机构地区：[1]南方医科大学南京临床学院(南京军区南京总医院)老年科,江苏南京210002 [2]南方医科大学南京临床学院(南京军区南京总医院)病理科,江苏南京210002 [3]南方医科大学南京临床学院(南京军区南京总医院)呼吸内科,江苏南京210002

出　　处：《医学研究生学报》2007年第8期823-826,898,共5页Journal of Medical Postgraduates

基　　金：江苏省自然科学基金资助项目(批准号:BK2004096)

摘　　要：目的:研究表明,一些生长因子及其受体在肺癌的治疗和预后判断中具有重要意义。该研究同时检测老年非小细胞肺癌(NSCLC)患者组织中的表皮生长因子受体(EGFR)、血管内皮生长因子(VEGF)以及Ki-67,以研究它们在肺癌组织中的表达及其之间的相互关系。方法:应用免疫组化法检测64例老年NSCLC患者中的EGFR、VEGF及Ki-67的表达水平。结果:EGFR、VEGF及Ki-67在肺癌组织中表达的阳性率分别为59.4%、57.8%和92.2%,正常组织的阳性率分别为0,9.52%和4.76%,差异均有显著性意义(P<0.05)。EGFR表达水平与肺癌患者的病理类型、分化程度、TNM分期和是否有淋巴结转移密切相关(P<0.05)。VEGF表达水平与肺癌患者的病理类型、分化程度和是否有淋巴结转移密切相关(P<0.05)。Ki-67表达水平与肺癌患者的分化程度和TNM分期密切相关(P<0.05)。结论:采用免疫组化法同时检测肺癌中的多种生物指标简易可行,为临床医师对患者的分期和预后提供重要信息,也为老年NSCLC患者分子靶向的个体化治疗提供理论依据。Objective：Studies suggested that some growth factors and their receptors play important roles in the treatment and prognosis of lung cancer. In this study we investigated the expression of epidermal growth factor receptor （EGFR）, vascular endothelial growth factor （VEGF）, and Ki-67 simultaneously in the tissues of aged patients with non-small cell lung cancer （NSCLC）. Methods ： The expression levels of EGFR, VEGF, and Ki-67 in 64 cases of aged patients with NSCLC were detected by immunohistochemistry staining. Results：The positive expression of EGFR, VEGF and Ki-67 in the tissue of lung cancer was 59.4% ,57.8% and 92.2%, respectively. It is different significantly while compared with control group of benign tissues. The expression levels of EGFR and VEGF are correlated significantly with the pathologic type, differential degree, TNM stage and lymphatic metastasis. The expression level of Ki-67 is related to differential degree and TNM stage of lung cancer. Conclusion.The method of immunohistochemistry to detect multiple biological markers simultaneously is simple and feasible. It can supply important information for the staging and prognoses of patients with NSCLC, and more than that, it can also provide the theoretic basis for the individualized molecular targeting therapy of NSCLC.

关 键 词：表皮生长因子受体 血管内皮生长因子 KI-67 老年患者 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]