人类软骨糖蛋白39在子宫内膜癌中的表达及临床意义  

The Expression and the Significance of YKL-40 in Endometrial Carcinoma

作　　者：郑建华[1] 彭春杰[1] 刘运铎[1] 孙宇辉[1] 王宇光[1] 韩旭[1] 韩世愈[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院妇产科,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2007年第8期568-570,共3页Heilongjiang Medical Journal

基　　金：黑龙江省教育厅一般研究资助项目(编号:10551155)

摘　　要：目的探讨子宫内膜癌组织中人类软骨糖蛋白39(YKL-40)的表达及其临床意义。方法采用免疫组织化学二步法检测47例子宫内膜癌和20例正常子宫内膜(对照组)中YKL-40的表达。结果YKL-40在子宫内膜癌组和对照组中阳性表达率分别为59.57%、15.00%,两组比较有明显差异(P<0.05)。YKL-40的表达与组织学分级有关,而与临床分期、组织类型、淋巴结转移、年龄、肌层浸润有关。结论YKL-40的异常表达可能在子宫内膜癌的发生、发展过程中起着重要作用。检测YKL-40对子宫内膜癌的恶性程度及判断预后具有重要的临床意义。Objective To explore the expression and clinical significance of YKL-40 in endometrial carcinoma.Methods Using Immunohistoehernical method, the expression of YKL - 40 was examined in 47 endornetrial carcinoma samples and 20 normal endometrium samples（control group）. Results The positive expression rates of YKL - 40 in the endometrial carcinomas and the control group were 59.57% and 15.00% ,and the difference between the two groups was sigrificant（ P 〈 0.05）. The expression of YKL- 40 was significantly correlated with cell differentiation,but not with clinical stages, histilogical type,lympnode metastasis,ages and myomettial invasion of endometrial carcinoma. Conclusion The expression of YKL-40 closely related to the carcinogenesis and development of the endometrial carcinomal turaorigenesis. Detection of YKL- 40 may be helpful to evaluate malignant degree and prognosis of endometrial carcinoma.

关 键 词：子宫内膜癌 人类软骨糖蛋白39 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]