国产紫杉醇治疗晚期卵巢癌32例临床分析  

China Made Paclitaxel in the Treatment of Advanced Ovarian Cancer: A Clinical Analysis of 32 Cases

作　　者：刘丽影[1] 洪婉君[1] 张蓉[1] 吴令英[1] 晁红霞[1] 孙晓光[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院妇瘤科

出　　处：《中华妇产科杂志》1997年第4期222-225,共4页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：探讨国产紫杉醇治疗晚期卵巢上皮性癌的疗效及其毒性。方法：３２例患者分为两组。单药组：１２例，紫杉醇剂量为１７５ｍｇ／ｍ２，溶于５％葡萄糖５００ｍｌ中，静脉滴注３小时，用于既往无化疗或仅用过１个疗程化疗的患者。联合组：２０例，第１天用紫杉醇，剂量为１３５ｍｇ／ｍ２，溶于５％葡萄糖５００ｍｌ，静脉滴注３小时，第２天用顺铂，７０～８０ｍｇ／ｍ２或卡铂３００ｍｇ／ｍ２，静脉滴注，主要用于顺铂化疗后肿瘤未控或复发患者。两组均为每４周１个疗程，除用药１个疗程后肿瘤进展而停药外，至少２个疗程。结果：全组有效率为３９％，单药组和联合组各为２７％和４５％。主要毒性包括中度骨髓抑制、末梢神经病变（肌肉痛、关节痛、末梢神经炎）及严重脱发等，但无过敏反应。１例死于肠穿孔。结论：国产紫杉醇是治疗卵巢癌的有效药物，特别是与顺铂联合用药，可用于顺铂耐药的复发或未控卵巢癌患者。其药物毒性是可耐受的。Objective: To study the effect and toxicities of China made paclitaxel in the treatment of advanced epithelial ovarian carcinoma. Methods: Thirty two patients were divided into two groups single paclitaxel group (SPG): paclitaxel was only given to twelve untreated patients or those who had been given only one course of chemotherapy at a dose of 175 mg/m 2 in 5% glucose 500 ml, iv for 3 hours; and combined paclitaxel group (CPG): paclitaxel 135 mg/m 2 in 5% glucose 55 ml, iv for 3 hours on day 1 plus cisplatin 70～80 mg/m 2 or carboplatin 300 mg/m 2, iv on day 2, was administered to 20 patients with persistent or recurrent tumor after platinum based chemotherapy. Four weeks were defined as one course in both groups. At least two courses were given except those with tumor progression after one course. Resutls: The overall response rate was 39%. It was 27% and 45% in the SPG and CPG. The chief side effects were moderate myelosuppression, peripheral neuropathy (myalgia, arthralgia, peripheral neuritis), severe alopecia, etc., but no hypersensitivity. One patient died from intestinal perforation. Conclusions: China made paclitaxel is effective as in treating ovarian carcinoma especially for platinum resistant patients. The toxic effects are tolerable to the patients.

关 键 词：卵巢肿瘤 紫杉醇 药物疗法 临床分析 

分 类 号：R737.310.5[医药卫生—肿瘤]