电化学治疗中晚期肺癌的临床效果  

Effectiveness of Electrochemical Therapy in the Treatment of Lung Cancer

作　　者：辛育龄[1] 薛复舟[1] 宋玉忱[1] 权宽宏[1] 葛炳生[1] 赵凤瑞[1] 

机构地区：[1]中日友好医院

出　　处：《中华胸心血管外科杂志》1997年第3期154-158,共5页Chinese Journal of Thoracic and Cardiovascular Surgery

摘　　要：应用电化学治疗不适宜手术切除的中晚期肺癌或经放、化疗无效的５９３例病人，包括年老体弱或有高血压、冠心病、糖尿病、肝肾功能不全者１５１例，经放化疗无效或未完成者１３８例，曾仅接受中医治疗但肿瘤继续增大者８３例，消化道癌术后肺内转移５２例，开胸探查手术１６９例。治疗方法为应用直流电治癌仪，将特制铂金电极针插入肿瘤内，针间距离以２ｃｍ为宜，电压调至８Ｖ左右，电流为６０～８０ｍＡ，按肿瘤直径每１ｃｍ给１００库仑（Ｃ）。结果１年内近期疗效显示获ＣＲ１５５例（２６１％），ＰＲ２６８例（４５１％），ＮＣ８９例（１５０％），ＰＤ８１例（１３０％）；ＣＲ和ＰＲ评为有效，占７１３％。远期随访结果示生存１年以上者共５０８例（８５６％），生存２年者４４０例（７４１％），生存３年者３３４例（５６３％），生存４年者２３２例（３９１％），生存５年者１６９例（２８４％）。结论：电化学治疗适应证为不能手术的中晚期肺癌或开胸后肿瘤不能切除者，放化疗无效者。尤其是对＞８ｃｍ的巨块肺癌，更宜采用电化学和放化疗相结合的综合方法。本疗法具有简便、安全、有效、创伤小、恢复快的优点。This paper dealt with the clincal effectiveness of electrochemical therapy in the treatment of 593 cases of middle and late staged lung cancer from 1987 to 1992.Among them,there were 445 males and 148 females,with an average age of 51.5.Pathological diagnosis was:Squamous cell carcinoma 236 cases,adenocarcinoma 159,small cell carcinoma 98,undifferentiated cacinoma 35,and adeno squamous cell carcinoma 65.According to the standard of TNM staging recommended by UICC in 1988,the stages were:T1 none,T2 198,T3 287,and T4 108.The cases of T3 and T4 dominated the group (67.0%).The diameters of tumor masses were:4.0～6.0cm in 129 cases,6.1～8.0cm in 225,8.1～10.0cm in 158,and greater than 10.0cm in 83.The percentage of cases greater than 8.0cm was 40.3%.All patients were inoperable,due to:(1)old age(81 cases were 65～78 yeas old),hypertension and coronary heart disease(63 cases),diabetes or dys functions of liver and kidney;(2)those not responding to radio or chemotherapy or could not finish radio or chemotherapy(198 cases);(3)those treated with Chinese traditional medicine but the tumor size still increased(83 cases);(4)those who received thoracotomy and cancer was fornd inoperable(169 cases);and (5)metastatic cancers in the lung after resection of cancers of breast,colon and kidney (52 cases).Method:Platinum electrodes(a 6mm in diameter) were inserted transcutaneously into tumor under the X ray monitoring and connected with the ECT apparatus to start treatment.The voltage was 6.0～8.0V.The diameter of 'killing' area of each electrode was about 2.0cm,hence,the number of electrodes needed could be determined according to the size of tumor mass.Therapeutic effectiveness:According to the evaluation standard set by WHO,the effectiveness of ECT on 593 cases was:CR(complete remission) 155 cases,PR(partial remission) 268,NC(no change) 89,and PD 81.The total effective rate of CR+PR was 71.3%(423/593).All patients were followed up from one to five years.There were 85 dea ths in one year andother 67 cases were lost in fe

关 键 词：肺肿瘤 电化学疗法 

分 类 号：R734.205[医药卫生—肿瘤]