慢性利血平抑郁模型大鼠脑内游离钙离子、钙调素和环核苷酸含量的变化  

Change of free calcium ion, calmodulin and cyclic adenylic acid contents in reserpine-induced chronic depression rat brain

作　　者：金光亮[1,2] 周东丰[1,2] 郭霞珍[1,2] 苏晶 梁怡[1,2] 程士德 齐治家[1,2] 

机构地区：[1]北京中医药大学 [2]北京医科大学精神卫生研究所

出　　处：《中华精神科杂志》1997年第2期67-69,共3页Chinese Journal of Psychiatry

基　　金：国家教委博士点专项基金

摘　　要：为探讨利血平致抑郁及阿米替林抗抑郁的机理，将Ｗｉｓｔａｒ雄性大鼠随机分为对照组、利血平模型组和利血平加阿米替林组，测定了大鼠脑内游离钙离子、钙调素、环核苷酸含量变化。结果显示，模型大鼠脑内游离钙离子、钙调素和环核苷酸含量降低，阿米替林可使模型大鼠脑内游离钙离子、钙调素浓度升高，而对环核苷酸则无影响。提示利血平致抑郁的机理与２条第二信使通路均有关，而阿米替林则可能是通过作用于钙信号系统发挥其抗抑郁作用。In order to investigate the mechanism of depression induced by reserpine and antidepression of amitriptyline, male Wistar rats were randomly allocated to three groups as follows: control, reserpine model and reserpine plus amitriptyline. The concentrations of free calcium ion, calmodulin and cyclic adenylic acid in the rat brain were determined. The results showed that the concentrations of free calcium ion, calmodulin and cyclic adenylic acid in the model rats brain were significantly lower. The concentrations of calcium ion, calmodulin but not cyclic adenylic acid was increased after amitriptyline treatment. It suggested that the mechanism of depression induced by reserpine was associated with the two second messenger pathways, and the mechanism of antidepression of amitriptyline was related to calcium messenger system.

关 键 词：抑郁症 疾病模型 利血平 钙 调钙蛋白 环核苷酸 

分 类 号：R749.41[医药卫生—神经病学与精神病学]