氟西汀治疗抑郁症的多中心开放性对照研究  

A multicenter open-controlled study of fluoxetine in the treatment of major depression

作　　者：施慎逊[1,2,3,4,5,6] 张明园[1,2,3,4,5,6] 陆峥[1,2,3,4,5,6] 方贻儒 杨晓敏[1,2,3,4,5,6] 盛尤荣 肖泽萍[1,2,3,4,5,6] 田运华 秦英绂[1,2,3,4,5,6] 黄淑珍 吉中孚[1,2,3,4,5,6] 陈国强 许行建 张晋碚 

机构地区：[1]上海市精神卫生中心 [2]北京安定医院 [3]北京回龙观医院 [4]广州市精神病院 [5]广州医科大学第二附属医院 [6]中山医科大学第三附属医院

出　　处：《中华精神科杂志》1997年第2期74-78,共5页Chinese Journal of Psychiatry

摘　　要：为观察进口氟西汀（百忧解）对中国抑郁症病人的疗效和不良反应，进行了多中心开放性对照研究，对照药物为阿米替林。共１１０例，其中氟西汀治疗５９例，阿米替林治疗５１例。年龄１９～６４岁，符合美国精神障碍诊断统计手册第３版修订版抑郁症诊断标准，Ｈａｍｉｌｔｏｎ抑郁量表（ＨＡＭＤ，２１项）≥１８分，疗程６周。予临床疗效评定和ＨＡＭＤ、临床总体评定量表、副反应量表评定。结果显示，氟西汀抗抑郁疗效肯定，显效率（８３．０％）与阿米替林相近，见效时间２～４周，不良反应明显低于阿米替林。提示氟西汀治疗抑郁症有效、安全。The purpose of the study was to determine the effectiveness of fluoxetine (Prozac) in patients with major depression and to evaluate its safety. Treatment with fluoxetine in 59 patients was compared with treatment with amitriptyline in 51 patients in a multicenter, randomized, 6-week open trial study. All patients who entered into the study met DSM-III-R criteria for major depression, with a score at least 18 on the 21-item Hamilton Depression Rating Scale (HAMD). The age of the patients ranged 19～64 years. HAMD, Clinical Global Impression (CGI) and Treatment Emergent Symptom Scale (TESS) were used to assess the therapeutic efficacy and side effect. The result showed that fluoxetine was as effective as amitriptyline for the treatment of major depression, with a positive resonse between 2 and 4 week and a significant improvement rate of 83.0%. Fewer side effects were noted with fluoxetine treatment than with amitriptyline. The results indicated that fluoxetine was effective in the treatment of major depression and was generally well tolerated.

关 键 词：抑郁症 氟西汀 药物疗法 

分 类 号：R749.410.5[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]