精神分裂症患者外周血T淋巴细胞亚群和异常淋巴细胞的检测  

Analysis on T lymphocyte subgroups and atypical lymphocytes in peripheral blood of schizophrenics

作　　者：项春兰[1] 项春晓[1] 项全富 

机构地区：[1]辽宁省精神卫生中心

出　　处：《中华精神科杂志》1997年第2期87-89,共3页Chinese Journal of Psychiatry

摘　　要：为探讨精神分裂症的发病机理，应用抗人Ｔ淋巴细胞单克隆抗体ＯＫＴ系统，间接葡萄球菌Ａ蛋白花环法，检测４７例精神分裂症外周血Ｔ淋巴细胞亚群；应用姬姆萨染色法，检测８７例精神分裂症外周血涂片异常淋巴细胞；并与２６名正常人对比。结果显示，精神分裂症患者的ＯＫＴ＋３（Ｐ＜０．０１）、ＯＫＴ＋４（Ｐ＜０．０５）、ＯＫＴ＋４／ＯＫＴ＋８（Ｐ＜０．０１）均较正常人显著减少，异常淋巴细胞显著增多（Ｐ＜０．０１）。５７例服用与３０例未服用抗精神病药物的患者的异常淋巴细胞差异无显著性（Ｐ＞０．０５）。提示精神分裂症确有免疫功能异常，异常淋巴细胞的改变与应用抗精神病药无明显相关。In order to explore the pathogenesis of schizophrenia, the T lymphocyte subgroups in peripheral blood of 47 schizophrenics were measured using anti human T lymphocyte monoclonal antibody OKT system and indirect staphylococcic A protein rosette, as well as the atypical lymphocytes in peripheral blood of 87 schizophrenics by Giemsa staining. Both OKT + 3 and OKT + 4/OKT + 8 were significantly lower but the percentrage of atypical lymphocytes was significantly higher in patients as compared with 26 healthy volunteers. No significant difference in percentage of atypical lymphocytes was observed between 30 patients with and 57 patients without neuroleptics treatment. The result found the percentage of atypical lymphocytes was not changed by antipsychotic medication and immunologic alteration existed in schizophrenia patients.

关 键 词：精神分裂症 T淋巴细胞亚群 异常淋巴细胞 

分 类 号：R749.3[医药卫生—神经病学与精神病学]