胃癌E-Cadherins表达的研究  

A Study of Expression of E-Cadherins in Gastric Carcinoma

作　　者：蔡建春[1] 张祥福[1] 陈治平[2] 王瑞年[3] 江绍基[4] 

机构地区：[1]福建医科大学附属协和医院,福州350001 [2]上海第二医科大学附属仁济医院,上海200001 [3]上海第二医科大学病理教研室,上海200025 [4]上海市消化疾病研究所,上海200001

出　　处：《浙江肿瘤》1997年第2期79-81,共3页

摘　　要：目的：研究钙离子依赖细胞-细胞间粘附分子E-Cadherins（Eg和Uvomorulin）在不同生长方式胃癌中的表达，探讨胃癌的闵锡钧分类。方法；应用单克隆抗体，免疫组织化学技术对46例新鲜胃癌标本中E-Cadherins进行检测。结果：E-Cadherins在胃正常小凹上皮细胞，慢性胃炎小凹上皮细胞和肠化腺体中呈均质性表达，然而在胃癌细胞中却出现异质性减少至消失的表达，这种表现尤其存在于闵锡钧分类的浸润型生长方式胃癌（24／24，100％）和分化不良的胃癌（2／31，84％），且呈分散单个浸润的胃癌细胞明显缺乏这种粘附分子。结论：E-Cadherins的存在与否可能决定着胃癌的生长方式和分化程度，它可以解释胃癌闵锡钧分类发病机理的～个方面。Purpose; To study the expression of intrecellular cell-cell adhesion molecules- E-Cadherins (E9 and Uvomorulin) for elucidating the pathogenesis of molecular basis in Ming's classfication of gastric carcinoma according to its growth pathern. Method: ECadherins were examined immunohistochemically in 46 cases of surgical specimens of gastric carcinomas, using MAb to E-Cadherins.Results: The E-Cadherins are expressed homogeneously both in normal foveolar epithelium, and in gastric epithelium or intestinal metaplastic glandular epithellum in chronic gastritis. In the latter condition, it is usually polarized along the apical border of glands. However, it displays heterogeneous reduced expression or lost in gastric carcinoma, esPecially in infiltrative type of gastric carcinoma according to Ming's classfication (24 /24, 100 % ), and also in poorly differentiated adenocarcinoma (26/31, 84 % ). The singly scattered neoplastic cells usually lack the expression of adhesion molecules. Conclusion: The results demonstrate that the expression of E-Cadherins is different in different types of gastric carcinoma according to its growth pattern of different degree of differentiation. They may form the molecufar basis for the pathogenesis of Ming's classfication of gastric carcinoma.

关 键 词：钙依赖 细胞粘附分子 胃肿瘤 闵锡钧分类 

分 类 号：R735.2[医药卫生—肿瘤]