22例胃粘膜相关淋巴瘤临床病理及免疫表型分析  

Clinicopathologic Features and Immunophenotyping of 22 Cases of Mucosa-associated Lymphold Tissue Lymphomas

作　　者：孙文勇[1] 张谷[1] 胡锦林[1] 

机构地区：[1]浙江省肿瘤医院,杭州310022

出　　处：《浙江肿瘤》1997年第2期91-92,共2页

摘　　要：目的：探讨胃粘膜相关淋巴瘤的临床病理特点。方法：收集22例胃原发性恶性淋巴瘤.应用MALT概念进行形态学及免疫组化分析。结果；本级资料显示临床以中年人多见．男女性别之比为1.4：1。病变好发于胃窦、体部。22例经免疫组化证实均为B细胞性淋巴瘤。其中6例病理形态学呈典型MALT淋巴瘤，13例呈不典型MALT淋巴瘤。3例肿瘤由单一高度恶性中心母细胞样细胞组成，其中2例内可见LEL现象和浆细胞浸润。结论：胃原发性B细胞性淋巴瘤均为MALT淋巴瘤。单一星高度恶性图像的淋巴瘤可能是MALT淋巴瘤转化的一个阶段。Purpose: To study the clinicopathologic features of mucosa-associated lymphoid tissue(MALT) lymphomas. Method:22 cases of malignant gastric lymphomas were studled by means of MALT classification and immunophenotyping. Results: The clinical features shown that the MALT mainly occured in the patients with middle age, and the sex ratio was 1. 4:1 (male :female); MALT lesions were usually found in antrum pyloricum and corpus ventriculi of stomach. All cases were detected to be B-cell type of lymphomas with the method of immunohistochemistry. Among thcsc, six wcre of typical types, 13 were of non-typlcal. In 3 cases that thc lesions were seen Pure malignant cclls of central blast-cell type, two were of LEL type and infiltrated with plasm Cell. Conclusion: The findings suggest that all of the primary gastric B-cell lymphomas are lymphomas with MALT, and the stage of lymphomas with pure and high-malignant cell type may be the key point in the transformation of MALT lymphomas.

关 键 词：胃粘膜相关性 淋巴瘤 免疫组化 病理 

分 类 号：R735.203[医药卫生—肿瘤]