葛根提取物对糖尿病大鼠肾脏功能的影响  

Effect of Kudzu Extract on Kidney Function of Rats with Diabetes

作　　者：曾明[1] 郑水庆[2] 陶凯忠[3] 王金萍[1] 边佳明[1] 徐宏发[4] 

机构地区：[1]北京军区总医院药理科,北京100700 [2]第二军医大学药学院,上海200433 [3]第二军医大学海医系,上海200433 [4]华东师范大学生命科学院,上海200062

出　　处：《中国实验方剂学杂志》2007年第8期42-44,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察葛根提取物对糖尿病大鼠肾功能的影响,探讨其作用机理。方法:采用链脲霉素复制糖尿病肾病大鼠模型,以氨基胍作阳性药物对照,观察葛根提取物对其空腹血糖、血清果糖胺、尿素氮、肌酐,血浆内皮素及6-酮-前列腺素的影响。结果:葛根提取物可降低糖尿病大鼠血糖、血清果糖胺、尿素氮、肌酐、血浆内皮素及6-酮-前列腺素的水平,与模型组相比有显著差异(P<0.01或P<0.05)。结论:葛根提取物具有防治糖尿病大鼠肾病的作用。Objective：To observe the effects of Kudzu extract on kidney function in rats with diabetic nephropathy （DN） ,and to probe its mechanism. Methods：The rat model of diabetic nep effects of TFP on diabetic rats were detected by blood sugar before meal, the hropathy was induced by streptozotocin. The concentration of fructosamine, urea nitrogen, creatinine in blood serum, and levels of ET,6-keto-PGF1 in plasma, compared with aminoguanidin treatment. Results：The Kudzu extract could decrease the level of blood sugar, the concentrations of fructosamine, urea nitrogen, creatinine in blood serum, and levels of ET, 6-keto-PGF1 in plasma, comparing to that of the diabetic model group （ P 〈 O. 01, or P 〈 0. 05 ） remarkably. Conclusion：The Kudzu extract has preventive and therapeutic effects on DN.

关 键 词：葛根提取物 糖尿病大鼠 肾脏功能 

分 类 号：R285.5[医药卫生—中药学]