一种新的脂肪细胞源性血管舒张因子  

Adipocyte-derived relaxing factor,a new vasodilative factor

作　　者：王皓帆[1] 王华东[2] 屈洋[2] 

机构地区：[1]中山大学中山医学院,广东广州510080 [2]暨南大学医学院病理生理教研室,广东广州510632

出　　处：《中国病理生理杂志》2007年第8期1649-1653,共5页Chinese Journal of Pathophysiology

摘　　要：Although our knowledge of ADRF(adipocyte-derived relaxing factor) is extremely limited,the little that is known has already revealed a promising future in this newly found factor.Firstly,it is secreted by adipose tissue,which is a abundantly and extensively distributed in human body and has become a hot spot for research work in recent years.Secondly,ADRF has shown a significant vasodilative action in a considerable number of experiments conducted on arteries of various sizes,from different body parts of different species of animals,including human.In this article,we introduce the development of ADRF research,sum up its known properties,including its Ca2+,protein tyrosine kinase,and protein kinase A dependent releasing,K+ channel mediated functioning,and interfered effect in different pathological models,and propose problems surrounding this factor and directions for future research work.Although our knowledge of ADRF （ adipocyte - derived relaxing factor） is extremely limited, the little that is known has already revealed a promising future in this newly found factor. Firstly, it is secreted by adipose tissue, which is a abundantly and extensively distributed in human body and has become a hot spot for research work in recent years. Secondly, ADRF has shown a significant vasodilative action in a considerable number of experiments conducted on arteries of various sizes, from different body parts of different species of animals, including human. In this article, we intreduce the development of ADRF research, sum up its known properties, including its Ca^2＋ , protein tyrosine kinase, and protein kinase A dependent releasing, K^＋ channel mediated functioning, and interfered effect in different pathological models, and propose problems surrounding this factor and directions for future research work.

关 键 词：脂细胞 血管舒张因子 钾通道 高血压 

分 类 号：R363[医药卫生—病理学]