纳洛酮冲击疗法、纳曲酮长效缓释剂包埋术的临床研究  

Clinical analysis in heroin addicts by the rapid and high dose naloxone therapy and naltrexon long slow release dose wrap operations

作　　者：王文甫[1] 肖杰屏[1] 刘国阳[1] 陈辞珍[1] 

机构地区：[1]湖南省脑科医院戒毒中心,长沙410007

出　　处：《中国药物滥用防治杂志》2007年第4期190-193,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:验证纳洛酮(NLX)冲击治疗、纳曲酮长效缓释剂包埋术的临床效果。方法:A组:30例海洛因依赖者在住院3天内完成NLX冲击治疗,次日进行纳曲酮长效缓释剂包埋术,观察术后戒断症状、不良反应及随访出院后相关情况;B组:同期内30例只进行纳洛酮冲击治疗,比较冲击治疗中及以后戒断症状及不良反应情况;C组:30例常规美沙酮替代递减脱毒,比较三组防复吸效能。结果:A组:30例患者平均住院2.3±0.6天一次性NLX冲击治疗成功,全部于次日下午进行包埋术,术后当天出院者6例,次日出院者20例,第三天出院者4例。没有1例出院后有明显戒断症状,不良反应,平均住院4.4±0.8天;B组:在纳洛酮冲击治疗中及以后相关情况与A组比较均无差异;防复吸效能:A组只一例包埋后长期滥用海洛因,B组半年操守率26%,C组半年操守率为0。结论:NLX冲击疗法治疗时间短、脱毒快、彻底、成功率高、经得起临床验证,纳曲酮长效缓释剂有较好的防复吸效能。Objective： The evaluation of the Naltrexone long slow release wrap operation had completed and its effect after rapid and high dose of NLX therapy. Methods： A group：30 patients had completed rapid and high dose NLX therapy in 3 days. NTX long slow release dose wrap operation had completed in the second afternoon. Withdrawal Symptoms and side effects was observed and the Outpatients were phoned. B group： 30 patients had completed rapid and high dose NLX therapy only. C group：30 patients had completed Methadone therapy. The withdrawal symptoms and side effects and prevention of relapse was compared. Results： the average time of from admission to the treatment was 2.3±0.6 days A group. All patients was operated in the next afternoon. The that bay of operation oubpatients was 6 cases, the day Second was 20 cases. The dieb tert was 4 cases. The time of average inpatients was 4.4± 0.8 day. Withdrawal symptoms and side effects was a little. The abstinence rate in 6 months in A group was higher （one patient was abused heroin for a long time） than that of B group （26%） and C group （0%）. Conclusion： the time of dotoxification of rapid and high dose of the therapy was Rapid. Short and cure rate of the therapy was higher than the clinical effect was affirmed and therapy may be spread in clinic, the Naltrexone long slow release wrap prevention of relapse was effect.

关 键 词：纳洛酮冲击疗法 纳曲酮长效缓释剂包埋术 海洛因依赖 防复吸 

分 类 号：R749.64[医药卫生—神经病学与精神病学]