人工肝支持系统治疗慢性重型肝炎的临床研究  

Clinical Study of Artificial Liver Support System on Treating Patients with Chronic Severe Hepatitis

作　　者：宋树芬[1] 

机构地区：[1]青岛市传染病医院,山东青岛266033

出　　处：《临床误诊误治》2007年第8期12-14,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的：探讨人工肝支持系统（artificial liver support system,ALSS）——血浆置换（plasma exchange,PE）、PE联合血浆吸附（plasma absorption,PA）治疗慢性重型肝炎的效果、时机及可行性。方法：将我院2003年8月-2006年3月收治的96例慢性重型肝炎患者随机分为治疗Ⅰ组、治疗Ⅱ组与对照组,3组均予内科综合治疗,在此基础上治疗Ⅰ组予PE治疗,治疗Ⅱ组加用PA治疗,观察3组治疗前后的症状、体征变化及相关实验室检查结果。结果：治疗Ⅰ组、治疗Ⅱ组经治疗后症状、体征均明显好转,总胆红素、丙氨酸转氨酶、天冬氨酸转氨酶、胆碱酯酶、凝血酶原活动度、血氨与对照组比较,差异具有非常显著统计学意义（P〈0.01）,治疗Ⅱ组优于治疗Ⅰ组,两组比较差异也具有非常显著统计学意义（P〈0.01）。结论：ALSS治疗慢性重型肝炎能显著改善肝功能,提高存活率,且安全可行。Objective ：To explore the therapeutic effect and Feasibility of artificial liver support system （ALSS）- plasma exchange （PE） ,plasma absorption（PA） combined with plasma exchange in patients with chronic severe hepatitis. Methods： 106 patients with chronic severe hepatitis were randomly divided into three groups： treatment group（ Ⅰ and Ⅱ group）and control group,in treatment group patients were treated with artificial liver support system on the basis of the conventional therapy. Patients in control group received the conventional therapy only. The clinical symptoms, signs and the laboratory data were collected before and after therapy. Results：After treating with ALSS,the clinical symptoms and signs of all patients were improved. TBIL、ChE、2PTA and NH3, were ameliorated （ P 〈 0.01 ） ; survival rate was also increased compared with control group （ P 〈 0.01 ）. Conclusion ： ALSS can effectively improve the clinical symptoms and the biochemical indicators,and canalso increase the survival rate.

关 键 词：肝炎 慢性 肝功能衰竭 血浆置换 血液滤过 

分 类 号：R575.1[医药卫生—消化系统]