中药鸦胆子对前列腺癌细胞超微结构及PSA水平的影响  

Effects of bruceolic oil emulsion on ultrastructure of prostatic carcinoma cell and PSA

作　　者：张秉鸿[1] 郭旻[2] 王庆堂[1] 王亮[1] 南勋义[3] 

机构地区：[1]成都军区总医院泌尿外科,四川成都610083 [2]宁夏银川市第一人民医院急诊科,宁夏银川750004 [3]西安交通大学第一临床医院泌尿外科,陕西西安710061

出　　处：《西南国防医药》2007年第4期402-404,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:探讨中药制剂鸦胆子油乳抑制前列腺癌的作用机制。方法:对11例C、D期前列腺癌患者(实验组)给予睾丸切除+氟他胺+鸦油乳治疗3个月,对照组6例C、D期患者仅给予睾丸切除+氟他胺治疗。治疗前后穿刺活检,以透射电镜观察癌细胞超微结构变化,并检测治疗前后两组患者血清PSA水平。结果:鸦油乳可直接破坏前列腺癌细胞膜、线粒体膜、内质网膜及核膜等膜性系统,使癌细胞变性并坏死;治疗后实验组血清PSA水平(11.32±3.12)ng/ml较对照组(18.87±2.86)ng/ml明显降低(P<0.05)。结论:鸦油乳主要通过破坏PCa细胞膜性系统杀伤癌细胞,并可使血清PSA明显降低。　Objective：To explore the mechanism of effects of bruceolic oil emulsion,a traditional Chinese medicine,on prostatic carcinoma.Methods：11 cases（experimental group）with prostatic carcinoma during stage C and D were treated by orchiectomy＋flutamide＋bruceolic oil emulsion,and another 6 ones（control group）with prostatic carcinoma during stage C and D were treated by orchiectomy and single flutamide.Before and after the treatment,the samples of their prostatic tissue were collected by puncturation and the ultrastructure of prostatic carcinoma cell was observed under transmission electron microscope.At the same time,the level of serum prostate specific antigen（PSA）was measured before and after the treatment.Results：It was found that bruceolic oil emulsion could break the membrane system of the cancer cell,including mitochondria membrane,endoplasmic reticulum and nuclear membrane,and make cancer cell apoptosis and necrosis.After the treatment,the level of serum PSA of the experimental group（11.32±3.12 ng/ml）was higher than that of the control group（18.87±2.86 ng/ml）（P〈0.05）.Conclusion：Bruceolic oil emulsion kills prostatic carcinoma cell by means of breaking membrane system of cancer cell and it can decrease the level of serum PSA.

关 键 词：鸦胆子 前列腺癌 前列腺特异性抗原 

分 类 号：R737.25[医药卫生—肿瘤]