葡萄糖苯氮芥衍生物的合成及抗肿瘤活性的研究  

Study of synthesis and anti-tumor activities of the benzene nitrogen mustard glucoside derivate

作　　者：刘铁梅[1] 朱光泽 卜丽梅[3] 李密阳[1] 张秀梅[1] 

机构地区：[1]吉林大学中日联谊医院检验科,吉林长春130033 [2]吉林中医药大学附属医院 [3]吉林大学第一临床学院

出　　处：《中国实验诊断学》2007年第8期1011-1013,共3页Chinese Journal of Laboratory Diagnosis

基　　金：本课题受吉林省科技厅基金资助(20020801)(20030708)

摘　　要：目的探讨新合成的葡萄糖苯氮芥衍生物对肝癌7721细胞的生长抑制及其诱导凋亡的作用。方法采用MTT,流式细胞术分析法。结果新合成的葡萄糖苯氮芥衍生物对正常细胞毒性较小,对7721有明显的细胞毒性,且通过流式细胞仪显示其诱导细胞凋亡。结论新合成的葡萄糖苯氮芥衍生物能明显抑制肝癌细胞的生长,诱导细胞凋亡是其抗肿瘤作用的主要机制之一。Objective To analyze the new synthesis benzene nitrogen mustard glucoside derivate inhibit the growth and induce the apoptosis of 7721 hepatumor cells. Methods The experiments were used by MTr and FCM. Results The new synthesis benzene nitrogen mustard glucoside derivate is much lower toxicity to normal cellsd and much higher toxicity to 7721 cells ＇compared with nitrogen mustard, meanwhile it induce the apoptosis of 7721 cells by the FCM. Conclusion The new synthesis benzene nitrogen mustard glucoside derivate can inhibit the growth of 7721 hepatumor ceils and induce the apoptosis which is the one of the main mechanisms of antiturnour.

关 键 词：靶向性治疗 氮芥 葡萄糖苯氮芥衍生物 肝癌7721细胞 

分 类 号：R914[医药卫生—药物化学] R73-36[医药卫生—药学]