肝癌化疗栓塞前后CT灌注特征与肿瘤血管生成相关性的实验研究  

Correlation study between CT perfusion features and tumoral angiogenesis of rabbit bearing VX2 tumor before and after chemoembolization

作　　者：陈昆涛[1] 何健垣[1] 郭瑞珍[1] 

机构地区：[1]遵义医学院第五附属医院,广东珠海519100

出　　处：《中国临床医学影像杂志》2007年第8期591-593,共3页Journal of China Clinic Medical Imaging

摘　　要：目的:建立兔VX2肝癌模型,探讨其化疗栓塞治疗前后CT灌注特征与肿瘤微血管密度(MVD)、血管内皮生长因子(VEGF)表达的相关性。材料和方法:选择60只新西兰大白兔作为实验动物。采用注射法将VX2瘤块接种于兔肝左叶。种植14天后随机分成对照组(n=30)和化疗栓塞组(n=30)。分别对两组动物作CT灌注成像检查及采用免疫组织化学方法测定病理标本的MVD、VEGF表达情况,并进行统计学分析。结果:CT灌注参数与MVD及VEGF表达程度呈正相关;化疗栓塞治疗组灌注参数、MVD及VEGF表达程度均明显低于对照组。结论:CT灌注成像特征可间接反映肿瘤血管生成,判断化疗栓塞的效果。Objective： To investigate the correlation between CT perfusion features and tumoral angiogenesis of rabbit bearing VX2 tumor before and after chemoembolization. Materials and Methods： Sixty New Zealand white rabbits, the rabbits were injected with VX2 tumor piece into the left lobe of the liver. Fourteen days after implantation the 60 rabbits were divided into contrast group （n=30） and chemoembolization group （n=30） randomly. CT perfusion was performed in the two groups. MVD and expressions of VEGF were examined by immunohistochemical techniques. Statistic analysis was made. Results： There were positive correlation between CT perfusion parameters with MVD and expressions of VEGF. CT perfusion parameters, MVD and expressions of VEGF of the chemoembolization group was lower than those of the contrast group. Conclusions： CT perfusion features can reflect tumoral angiogenesis indirectly, and can estimate the effect of chemoembolization.

关 键 词：肝肿瘤 体层摄影术 X线计算机 栓塞 治疗性 

分 类 号：R735.7[医药卫生—肿瘤] R814.42[医药卫生—临床医学]