药物致心律失常及其评价模型研究进展  

Development of Drug-induced Arrhythmias and its Models for Assessment

作　　者：岳慧杰[1] 王友群[1] 

机构地区：[1]中国药科大学药理研究室,南京210009

出　　处：《中国现代应用药学》2007年第4期285-288,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的综述药物致心律失常的可能机制,对模型做一简要回顾评价,为找出合适的临床前评价模型提供帮助。方法检索近几年的文献资料进行分析归纳。结果与讨论只有对药物致心律失常的机制充分掌握,才能建立合适的模型预防心律失常。OBJECTIVE To find suitable models for preclinical safety evaluation of drug-induced arrhythmias by summarizing the possible mechanisms and assessment models of drug-induced arrhythmias. METHODS Summarizing and analyzing the literatures and data published in the recent years. RESULTS AND CONCLUSION The design of suitable models to efficiently prevent arrhythmias was based on the sufficient understand of the exact mechanism for drug-induced arrhythmias.

关 键 词：药物致心律失常 长QT综合征 尖端扭转性室性心动过速 跨室壁复极化离散度 模型 

分 类 号：R972.2[医药卫生—药品] R965.1[医药卫生—药学]